Updated 02 June 2015

Antihistamine blocks hepatitis C infection

According US researchers, a cheap antihistamine may be useful in the treatment of hepatitis C.


A cheap allergy drug that is taken for coughing, sneezing and runny nose may be useful in treating the chronic liver infection hepatitis C, US researchers said Wednesday.

50 cents per pill

The antihistamine, called chlorcyclizine HCI, costs about 50 cents per pill, in sharp contrast to recent antiviral treatments that can cure hepatitis C for the first time, but at a hefty cost of at least $8,000 per four-month regimen.

Since some 185 million people worldwide suffer from hepatitis C, which can lead to cancer and cirrhosis of the liver, researchers said the new use for an old drug could offer hope for people particularly in Asia and Africa where the disease is endemic.

For the study, which appears in the journal Science Translational Medicine, researchers analysed a library of drugs already approved by the US Food and Drug Administration to find candidates that might be useful for treating hepatitis C.

Read: Allergies

They found that chlorcyclizine HCI, which was approved about five decades ago, blocks hepatitis C infection by preventing the virus from entering human liver cells.

Research using lab mice that carried human liver cells showed that the drug could block the virus and did not lead to drug resistance, a common problem in hepatitis C treatments.

The drug also worked well with other hepatitis C drugs to make those treatments more effective.

Anti-cancer, cholesterol and anti-malaria drugs useful

Other FDA-approved drugs have previously been shown to be useful for clinical treatment of hepatitis C, including the anti-cancer drugs erlotinib and dasatinib; the cholesterol drug ezetimibe; and the anti-malaria treatment ferroquine.

However, the antihistamine showed even "more compelling in vitro and in vivo activity against HCV infection than these drugs," said the study, led by Shanshan He at the National Institutes of Health in Bethesda, Maryland.

Read: Treating allergies

Since the drug, also known as CCZ, has already been shown to be safe in humans, researchers called for clinical studies to see how it works against hepatitis C in people.

"With its established clinical safety profile as an allergy medication, affordability, and a simple chemical structure for optimisation, CCZ represents a promising candidate for drug re-purposing and further development as an effective and accessible agent for treatment of HCV infection," the study said.

Not to be taken till proven safe

"People should not take CCZ to treat their hepatitis C until it has been demonstrated that CCZ can be used safely and effectively for that purpose," said study author T. Jake Liang, senior investigator at NIH's National Institute of Diabetes and Digestive and Kidney Diseases.

Read More:

8 of the strangest allergy cures from around the world 

Kids can get food allergies from donated blood 

Smog with pollen may mean even more sneezing

Image: Antihistamine tablets from Shutterstock


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Dr Morris is the Principal Allergist at the Cape Town and Johannesburg Allergy Clinics with postgraduate diplomas in Allergology, Dermatology, Paediatrics and Family Medicine dealing with both adult and childhood allergies.

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