There is no
high quality evidence that antioxidant supplements help to increase a woman's
chances of having a baby, according to the results of a new systematic review.
The review, published in The Cochrane Library, found women were no more likely
to conceive when taking oral antioxidants and that there was limited
information about potential harms.
quarter of couples planning a baby are thought to have difficulty conceiving.
Women undergoing fertility treatment often take dietary supplements, including
antioxidants, to try to increase their chances of becoming pregnant. However,
many antioxidant supplements taken to improve fertility are unregulated and
there is limited evidence on their safety and effects.
researchers analysed data from 28 trials involving a total of 3 548 women
attending fertility clinics. Antioxidants did not increase the women's chances
of conceiving or having a baby. The results show no significant increase in
women becoming pregnant when taking antioxidants compared to those taking
placebos or being given standard treatment, including folic acid.
is no evidence in this review that suggests taking an antioxidant is beneficial
for women who are trying to conceive," said lead researcher, Marian
Showell, who works in Obstetrics and Gynaecology at the University of Auckland
in Auckland, New Zealand.
Only 14 of
the trials reported on adverse effects such as miscarriage and ectopic
pregnancy. Women taking antioxidants experienced no more adverse effects
compared to those who received placebos or standard treatment.
the researchers considered the quality of the trials to be low or very low and
the number of different antioxidants tested made it difficult to make
comparisons. "We could not assess whether one antioxidant was better than
another," said Showell.