The Gauteng health department and the University of the Witwatersrand (Wits) on Thursday signed a pact to address health delivery problems, the university said.
The accord, endorsed in Pretoria, would seek to tackle needs such as essential equipment and life-saving machines at academic hospitals across the province.
The four hospitals forming part of the academic platform are the Chris Hani Baragwanath Academic Hospital, Charlotte Maxeke Johannesburg Academic Hospital, Helen Joseph Academic Hospital, and Rahima Moosa Mother and Child Hospital.
Wits rector Adam Habib said such projects were vital for the institution.
He said this move set the tone for the future for similar agreements.
"This event... symbolises how decisive and committed leadership can engage and resolve issues of concern to the benefit of all parties and South African citizens as a whole."