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Tuberculosis

17 November 2010

Possible TB treatment from cancer meds

A key enzyme in Mycobacterium tuberculosis that enables the microbe to reproduce rapidly could be a golden target for new drugs against tuberculosis.

A key enzyme in Mycobacterium tuberculosis that enables the microbe to reproduce rapidly could be a golden target for new drugs against tuberculosis (TB), according to a study published in Microbiology.

The researchers identified the three genes in M. tuberculosis that encode IMPDH and then screened a library of 16 compounds that were likely to impede its function to some extent. Of the 16 diphenyl urea (DPU) compounds, three were able to inhibit IMPDH by more than 90%, killing M. tuberculosis cells.

 

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