09 March 2009

40-winks may lead to stroke

What do mammograms, blood-sugar tests and daytime dozing have in common? All may offer clues that someone is headed for a stroke, new studies suggest.

What do mammograms, blood-sugar tests and daytime dozing have in common? All may offer clues that someone is headed for a stroke, new studies suggest.

Higher stroke risk was seen in women with artery build-ups accidentally revealed by mammograms, in non-diabetics starting to have insulin problems, and in older people who tend to nod off a lot.

People should not panic if they have one of these signs. But if grandma falls asleep in front of the TV all the time, it may be worth checking to see if she has a sleep disorder raising her risk of stroke, doctors say.

Likewise, a test that rules out breast cancer may give a valuable clue to heart disease and stroke risks - if radiologists report the findings to women and their doctors for follow-up. "You're getting information in two important areas," but people often focus on just the cancer risk, said Dr Philip Gorelick, neurology chief at the University of Illinois in Chicago. He is chairman of the International Stroke Conference, a medical meeting in New Orleans where the studies were presented.

Afternoon nap not healthy
Daytime drowsiness may be due to night-time sleep apnoea, a common condition where people briefly stop breathing, causing spikes in blood pressure as they startle awake. Snoring can be a sign, but doesn't always mean trouble - except for others trying to sleep.

"It's not healthy because you're not staying in your normal sleep pattern. You're waking up many times in the night and are tired during the day," Gorelick explained.

Columbia University researchers led by Bernadette Boden-Albala found that a simple scoring system to evaluate daytime dozing strongly predicted stroke risk. They asked 2 100 people, average age 73, how often they nodded off during specific situations during the day - watching TV, reading, sitting and talking to someone, sitting in traffic, or sitting quietly after lunch.

In the next two years, 40 had strokes and 127 had other blood vessel-related problems such as heart attacks or blood clots in the lungs. The odds of having a stroke were nearly five times greater among heavy dozers, and nearly three times greater among occasional dozers, compared with people who rarely nodded off. The chances of other vessel-related problems were higher, too.

Focus on unintentional dozing
Unintentional dozing is different from purposely taking a nap, although "we need to look at that" to see if regular siestas also are a sign of poor night-time sleep, Boden-Albala said.

Frequent dozers should talk to their doctors about being evaluated for a sleep disorder. Possible solutions include a device that helps maintain continuous air pressure, losing weight if they are overweight, and even surgery if the airway is obstructed.

The mammography study was led by medical student Amy Loden and Dr Paul Dale of the University of Missouri Medical School in Columbia, Mo. They studied calcium deposits in the walls of arteries that supply the breasts, which are different from the calcifications in breast tissue that can signal the presence of a tumour.

"Every time I see one I think, 'That woman has a breast full of calcifications. I wonder if her heart looks the same,"' said Dale, a cancer surgeon. He previously published studies tying these artery deposits to a higher risk of heart disease. In the new study, he and fellow researchers found these deposits in 11 percent of roughly 800 women having routine mammograms at their hospital.

Greater stroke risk identified
Next, they looked at the mammograms of 204 stroke patients and found the deposits in 56 percent of them - five times more often. Greater stroke risk was seen in women of all ages with the deposits, but especially among those in their forties and fifties.

"We're not saying just because you have these you're going to have a stroke - it's just identifying women at risk," Dale said.

He is starting a new study to see whether calcium deposits can be used to predict who will suffer strokes later, and thinks radiologists should report deposits to doctors so follow-up tests can be considered for stroke and heart disease.

Radiologists usually do not report artery deposits, which are more common as women age, said Dr Carol H. Lee, an American College of Radiology spokeswoman from Memorial Sloan-Kettering Cancer Centre in New York.

"I don't know that many radiologists emphasise it, especially in older people," she said. "It may be a simple marker" for the risk of a lot of things, said Dr Ralph Sacco, neurology chief at the University of Miami Miller School of Medicine.

Third study shows insulin-related risk
The third study looked at clues of stroke risk from a different test - HOMA, a ratio of blood-sugar and insulin levels measured after fasting. High scores signal insulin resistance, a condition where the body is not able to effectively use that hormone to turn food into energy, raising the risk of diabetes.

Dr Tatjana Rundek at the University of Miami led a study of 1 735 non-diabetic people, average age 68, participating in a long-running study of stroke risk in New York, funded by the federal government.

One-fourth had high HOMA scores, and in the next seven years, they had twice the risk of stroke compared to those with low scores. The test is not routinely done, but blood-sugar levels are frequently tested and may give a warning of more than diabetes risk, doctors said. – (Sapa)

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