Updated 15 January 2018

Toothache? Neanderthals might also have used aspirin

Research indicates that Neanderthals may even have understood the healing powers of penicillin 50 000 years ago.

Dental care was decidedly primitive back in the time of the Neanderthals.

But new research suggests these long-gone relatives of humans already had 21st century solutions to toothache – aspirin, and perhaps even penicillin.

The study was led by Laura Weyrich, of the Australian Centre for Ancient DNA (ACAD) at the University of Adelaide. Her team examined dental plaque from the remains of four Neanderthals found in caves in Belgium and Spain.

The study was published in the journal Nature.

Pre-historic plaque

This was the oldest such plaque ever to be genetically analysed – between 42 000 to 50 000 years old.

Weyrich said DNA analysis of ancient dental build-up can reveal a storehouse of knowledge.

"Dental plaque traps microorganisms that lived in the mouth and pathogens found in the respiratory and gastrointestinal tract," she explained in a university news release. Plaque also harbours "bits of food stuck in the teeth – preserving the DNA for thousands of years".

This means that the "DNA 'locked-up' in plaque represents a unique window into Neanderthal lifestyle – revealing new details of what they ate, what their health was like and how the environment impacted their behaviour," Weyrich said.

Dental abscess in Spanish Neanderthal

One of the most surprising finds was from the remains of just one of the Neanderthals in Spain, a male.

He "suffered from a dental abscess visible on the jawbone," said ACAD Director Alan Cooper. "The plaque showed that he also had an intestinal parasite that causes acute diarrhoea, so clearly he was quite sick."

But the DNA revealed unexpected information, Cooper said. This Neanderthal individual "was eating poplar, which contains the painkiller salicylic acid (the active ingredient of aspirin)," he noted.

Aspirin is only one of a number of analgesics (painkillers). Others are paracetamol, NSAIDs (non-steroidal anti-inflammatories) and opioids.

Even more intriguing, "we could also detect a natural antibiotic mould [penicillium] not seen in the other specimens," Cooper said.

Anti-inflammatory plants 

This suggests that "Neanderthals possessed a good knowledge of medicinal plants and their various anti-inflammatory and pain-relieving properties, and seemed to be self-medicating," according to Cooper.

"The use of antibiotics would be very surprising, as this is more than 40 000 years before we developed penicillin," he added. "Certainly our findings contrast markedly with the rather simplistic view of our ancient relatives in popular imagination."

The researchers also found that Neanderthals' diets changed based on location. Those who were found in the Belgium cave ate woolly rhinoceros and European wild sheep, supplemented with wild mushrooms, the researchers reported. Meanwhile, those in the Spanish cave had no signs of meat consumption but instead had a largely vegetarian diet of items such as pine nuts, moss, mushrooms and tree bark.

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Dr Imraan Hoosen qualified from the Medical University of South Africa in 1997. Together with his partner, Dr Hoosen now runs a group of dental practices around Johannesburg (Lesedi Private Hospital, Highlands North Medical Centre , Brenthurst Clinic, Parklane Clinic, Simmonds Street Medical and Dental Centre, Soni Medical Centre- Newclare). Dr Hoosen can be contacted on 011 933 4096.

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