Methylprednisolone is the active ingredient of Advantan cream (Nappi
code: 793108-020/039), Advantan ointment (Nappi code: 793086-035/043), Advantan
fatty ointment (Nappi code: 793116-023/031), Advantan milk (Nappi code:
883180-006) and Advantan scalp solution (Nappi code: 701417-001).
Methylprednisolone is a topical corticosteroid. Topical corticosteroids are
steroid medications that that are formulated for use on the skin. They reduce
inflammation and are effective for treating inflammatory skin conditions.
In South Africa methylprednisolone is registered for the treatment of
non-infected steroid responsive diseases and disorders affecting the skin.
This medication should be applied sparingly and as a thin, even layer to the
affected area of the skin. Do not apply to broken skin, or apply more than
Prolonged use on large surface areas, application of large amounts, or
covering the application site with dressings, may increase systemic absorption,
resulting in a decrease in the production of natural hormones by the adrenal
glands. Prolonged or excessive use of this medicine may lead
to thinning of the skin.
Do not apply to the face and avoid contact with the eyes.
Speak to your doctor before applying this medicine to infected skin.
How does methylprednisolone work?
When applied to the skin, methylprednisolone reduces the release of
inflammatory chemicals. This reduces inflammation and its associated
Drug schedule: schedule 4
Available as: methylprednisolone is available as cream, ointment,
fatty ointment, milk and scalp lotion.
What does it do? Methylprednisolone relieves inflammation of the
Overdose risk: low
Dependence risk: low
Is methylprednisolone available as a generic? no
Is methylprednisolone available on prescription only? no and yes
Stopping this medicine: do not stop using this medication abruptly as
it may cause a recurrence of the original symptoms being treated. Consult with
your doctor prior to discontinuing treatment.
Prolonged use: this medicine is not intended for long-term use as this
may lead to permanent skin changes. Duration of treatment should generally not
exceed four weeks.
Consult your doctor before using this drug if:
- you have a bacterial, fungal or viral skin infection
- you have porphyria
- you have skin ulcers/broken skin
- you have acne or rosacea
Pregnancy: avoid. It is unknown how this medication may affect your
baby. Consult your doctor before using this drug, or if you are planning to fall
Breastfeeding: avoid. It is unknown how this medication may affect
your baby. Consult your doctor before use.
Porphyria: avoid. This medication may cause serious adverse effects.
Consult your doctor before use.
Infants and children: avoid. No data available for use in
The elderly: no special precautions need to be taken.
Driving and hazardous work: no special precautions need to be
Alcohol: no special precautions need to be taken.
Possible side effects
| Side effects
|| Consult your doctor
|| Only if severe
|| In all cases |
Interactions are uncommon when this medication is used as directed.
A small overdose is no cause for concern. In case of intentional large
overdose, seek emergency medical attention.
Apply sparingly to the affected area once daily.
This material is not intended to substitute medical advice, but is for
informational purposes only.
Please consult a physician for specific treatment and