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Meds and you

27 September 2013

Clindamycin

Clindamycin is a broad-spectrum antibiotic effective in treating a variety of bacterial infections.

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Clindamycin is the active ingredient of Clindahexal (Nappi Code: 849960-002/010), Clindamycin-Fresenius (Nappi Code: 797847-006), Dalacin-C (Nappi Code: 717347-117/028 & 717355-004), Micro-Clindamycin (Nappi Code: 703672-002), Dalacin VC (Nappi Code: 818968-001) and Dalacin T (Nappi Code: 835757-005).

General information
Clindamycin is a broad-spectrum antibiotic effective in treating a variety of bacterial infections including infections of the respiratory tract, abdominal cavity, certain skin, soft tissue, dental, bone and joint infection caused by clindamycin sensitive organisms.

It is important to note that this medication is only effective against bacterial infections - if your infection is the result of a viral or fungal infection, it will be ineffective.

Antibiotic resistance occurs when a bacterium develops the ability to defend itself against the effect of an antibiotic. It may also occur with clindamycin. The most common causes for resistance are patients not completing prescribed antibiotic courses, allowing the bacteria to recover from treatment, and the use of antibiotics for non-bacterial infections, such as cold and flu.

Clindamycin is also available in a topical form, which is effective in treating acne, while a vaginal formulation is available for genital bacterial infections.

How does clindamycin work?
Clindamycin functions by inhibiting bacterial protein synthesis - it thus prevents bacteria from producing specific proteins essential for their survival.

Fast facts

Drug schedule: schedule 4
Available as: clindamycin is available as capsules, injections, topical and vaginal applications
What does it do? Clindamycin has an antibiotic action
Overdose risk: low
Dependence risk: low
Is clindamycin available as a generic? yes
Is clindamycin available on prescription only? yes

User information

Onset of effect: within 6 hours
Duration of action: up to 8 hours
Stopping this medicine: do not stop using clindamycin before you have completed the course prescribed by your doctor, even if you begin to feel better.
Prolonged use: clindamycin is generally used for short periods of time only. In rare cases it is used for prolonged periods of time - this may be associated with increased side effects and your prescriber should monitor you closely.

Special precautions
Consult your doctor before using this drug if:

Pregnancy: avoid. It is unknown how this medication may affect your baby. Consult your doctor before using this drug, or if you are planning to fall pregnant.
Breastfeeding: avoid. This medication is passed through breast milk and may affect your baby adversely. Consult your doctor before use.
Porphyria: avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.
Infants and children: this medication is safe for use in children at the recommended dose.
The elderly: no special precautions need to be taken.
Driving and hazardous work: no special precautions need to be taken.
Alcohol: avoid concomitant use of alcohol with this medication.

Possible side effects

Side Effect
Frequency
Consult your doctor

Common
Rare
Only if severe
In all cases
nausea
X

X

vomiting
X

X

diarrhoea
X

X

abdominal pain

X
X

sore/irritated throat

X

X
rash/itch

X

X
yellow tinge to eyes/skin

X

X
fever/chills

X

X
bloody diarrhoea

X

X
difficulty breathing/swallowing

X

X
swelling of lips/throat/tongue

X

X

Interactions

kaolin & pectin mixtures should be taken 2 hours before or after antibiotic to prevent a decrease in antibiotic absorption
suxamethonium risk of respiratory depression
oral contraception possible pill failure

Disease interactions
Consult your doctor before using this drug if you have liver or kidney disease, you have colitis, Crohn's disease, or any other intestinal disorder.

Overdose action
A small overdose is no cause for concern. In case of intentional large overdose seek emergency medical attention.

Recommended dosage
Adults:
Oral, 150-300 mg every 6 hours
IV or IM, 0.6-1.2g per day in 2-4 divided doses with a maximum daily dose of 4.8 g/day

This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.
 
 

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