Meds and you

27 September 2013


Buclizine is an antihistamine. They are drugs that counter the effect of histamine, a substance released by the body in large amounts during an allergic reaction.


Buclizine is the active ingredient of Longifene Syrup (Nappi code: 739197-002).

General information

Buclizine is an antihistamine. Antihistamines are drugs that counter the effect of histamine, a substance released by the body in large amounts during an allergic reaction.

In South Africa buclizine is registered for the treatment of the treatment of hay fever, nausea, food and drug interactions and to stimulate appetite.

Because this drug causes sedation you should take care when driving, or when you have to do anything that requires you to be alert. Avoid any other dangerous activity until you know how this medication affects you.

How does buclizine work?

When you are exposed to an allergen - something you are allergic to - your body reacts by producing chemical called histamine. Histamine causes the symptoms that we associate with allergy. Buclizine is an antihistamine, meaning that it counteracts the action of histamine to help relieve you of the symptoms of allergy.

Buclizine can also be used to prevent nausea. It blocks histamine receptors in an area of the brain known as the vomiting centre, effectively blocking nerve signals that would otherwise cause nausea.

Fast facts

Drug schedule: schedule 2

Available as: buclizine is available as syrup.

What does it do? Buclizine relieves allergies and nausea.

Overdose risk: medium

Dependence risk: low

Is buclizine available as a generic? no

Is buclizine available on prescription only? no

User information

Dietary advice: buclizine should be taken with food.

Stopping this medicine: treatment with this medication can be safely stopped when no longer needed.

Special precautions

Consult your doctor before using this drug if:

  • you have glaucoma
  • you have difficulty urinating
  • you have prostate problems
  • you have epilepsy
  • you have liver or kidney problems
  • you have heart disease
  • you are pregnant
  • you are taking other medication

Pregnancy: avoid. Potential risk to the foetus has been reported. Consult your doctor before use, or if you are planning to fall pregnant.

Breastfeeding: avoid. It is unknown how this medication may affect your baby. Consult your doctor before use.

Porphyria: avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.

The elderly: caution is advised in the elderly as side effects are more likely to occur.

Driving and hazardous work: this medication should be avoided as it may cause extreme sedation.

Alcohol: avoid concomitant use of alcohol with this medication.

Possible side effects

Side effects Frequency
Consult your doctor

Common Rare Only if severe In all cases
drowsiness x
appetite increase x
x x
low blood pressure
x x
dry mouth x
blurred vision
x x
difficulty urinating x

loss of co-ordination
x x
epigastric pain
x x
x x
skin rash


Drug interactions

barbiturates potential for enhanced sedation
benzodiazapines potential for enhanced sedation
hypnotics potential for enhanced sedation
sedatives potential for enhanced sedation

Overdose action

A small overdose is no cause for concern. In case of intentional large overdose, seek emergency medical attention.

Recommended dosage

Children 1-5 years: 5 - 10mg three times per day as needed.


This material is not intended to substitute medical advice, but is for informational purposes only.

Please consult a physician for specific treatment and recommendations.


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