Benserazide is not available as a product on its own.
Benserazide is a decarboxylase inhibitor. Decarboxylase inhibitors are drugs that prevent levodopa, another drug indicated for the treatment of Parkinson's disease, to be converted to dopamine before reaching the brain, thereby increasing the effect of levodopa and reducing the side effects of levodopa if converted to dopamine outside of the brain.
In South Africa benserazide is registered for the treatment of Parkinson's disease in combination with levodapa. It has no therapeutic effect on its own.
How it works
Benserazide is used in combination with levodopa to prevent the conversion of levodopa to dopamine prior to reaching the brain. Because benserazide cannot enter the brain like levodopa, levodopa will only be converted to dopamine within the brain - exactly where it is needed.
Drug schedule: schedule 4
What does it do? Benserazide enhances the effect of levodopa in the treatment of Parkinson’s disease and also reduces the side effects of levodopa.
Overdose risk: medium
Dependence risk: low
Is benserazide available on prescription only? yes
Pregnancy: avoid. It is unknown how this medication may affect your baby. Consult your doctor before using this drug, or if you are planning to fall pregnant.
Breastfeeding: avoid. It is unknown how this medication may affect your baby. Consult your doctor before use.
Porphyria: avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.
Infants and children: this medication is not intended for use in children.
Elderly: no special precautions need to be taken.
Driving and hazardous work: no special precautions need to be taken.
A small overdose is no cause for concern. In case of intentional large overdose seek emergency medical attention.
This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.