Lung cancer

Updated 28 August 2014

Experimental drug may extend lung cancer survival

A new "targeted" therapy might help extend the lives of patients with advanced lung cancer who have a relapse after their initial treatment

A new "targeted" therapy might help extend the lives of patients with advanced lung cancer who have a relapse after their initial treatment, a clinical trial suggests.

The drug, ramucirumab, improved survival by more than a month when combined with standard chemotherapy, researchers are scheduled to report Saturday at the American Society of Clinical Oncology annual meeting in Chicago.

Ramucirumab fights cancer by preventing the creation of new blood vessels in tumors, robbing them of needed nutrients and oxygen.

Read: New lung cancer guidelines can save more lives

The study found that the median overall survival in patients with advanced non-small cell lung cancer was 10.5 months for those taking ramucirumab plus chemotherapy, compared with 9.1 months for patients who received a placebo, or dummy drug, with their chemo.

However, the significance of this advance is subject to debate.

Currently, very limited chemotherapy options exist for patients whose lung cancer returns, said Dr. Maurice Perol, head of thoracic oncology at the Cancer Research Center of Lyon in France.

Those options provide relatively poor results, shrinking tumors only about 10 percent and extending patient survival by seven to nine months, he said.

"This is the first treatment in approximately a decade to improve the outcome of patients in the second-line setting," Perol said. "The survival improvement is significant because patients with advanced non-small cell lung cancer typically have a very short survival time following second-line therapy."

See more: Breath test may reveal early-stage lung cancer

The clinical trial involved 1,253 patients with stage IV non-small cell lung cancer that had progressed despite standard chemotherapy. Non-small cell lung cancer is the most common type of lung cancer.

All of the patients were treated with the chemotherapy drug docetaxel. Some, then, were randomly given ramucirumab as well, while others received a placebo.

Adding ramucirumab improved the effectiveness of chemotherapy, the investigators found, with nearly 23 percent of patients experiencing tumor shrinkage compared with 13.5 percent of those who received placebo.

Ramucirumab also improved survival against all types of non-small cell lung cancer, indicating that it could be useful in treating all patients battling a recurrence of this type of lung cancer, Perol said.

The progression-free survival periods for ramucirumab patients was 4.5 months, versus three months in the placebo group.

The experimental drug came with few serious side effects. "There was no increase in adverse events or in pulmonary hemorrhage [bleeding from the lung], which is one of the greatest potential risks," Perol said.

Read: Lung cancer tumours often harmless

The findings from the clinical trial don't represent a huge advance over current treatment, said Dr. Norman Edelman, senior medical advisor for the American Lung Association.

However, ramucirumab does show promise as part of a new class of targeted therapies, he added.

"I find this drug interesting because it represents an attempt to step beyond the usual cytotoxic agents. But on its own, it's not a remarkable breakthrough," Edelman said.

"Some people will have an extra year. Other people will have nothing," Edelman said. "And it won't be cheap. The new biologics are expensive. We're talking tens of thousands of dollars for cost of treatment. These are complicated decisions."

Read more: 

Gene testing may boost lung cancer survival
Blood protein might help early lung cancer detection 
New drug extends advanced lung cancer survival


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