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Infectious Diseases

05 August 2020

Gene study shows how coronavirus swept through cruise ship Diamond Princess

A genetic retracing of events shows the outbreak on the Diamond Princess likely stemmed from just one infected person, according to Japanese researchers.

  • Coronavirus led to hundreds of infections and seven deaths on the cruise ship Diamond Princess in February
  • The outbreak has been traced to just one person
  • Japanese researchers found that containment measures on the ship limited the spread of the virus 


The fate of more than 3 600 quarantined passengers and crew on the cruise ship Diamond Princess made headlines in the early weeks of the coronavirus pandemic in February.

An outbreak aboard the ship eventually led to nearly 700 infections and seven deaths from Covid-19.

Now, a genetic retracing of events shows the outbreak likely stemmed from just one infected person, with the virus spreading rapidly as people mingled at crowded shipboard events, Japanese researchers report.

One thing is certain, however: Quarantine and containment measures enacted after the virus was discovered did limit cases – and probably saved lives.

Movement restriction highly successful

The first known case of coronavirus infection on the Diamond Princess was reported on 1 February in an ill 80-year-old passenger who left the ship in Hong Kong on Jan. 25.

By 4 February, a quarantine was in place throughout the ship and passengers were largely restricted to their cabins.

At that point, the incidence of new cases "abruptly declined", according to a team led by Makoto Kuroda, of the National Institute of Infectious Diseases, in Tokyo.

That indicates that "the movement restriction policy was highly successful in greatly reducing the number of secondary transmissions on board the Diamond Princess," the researchers reported.

One prior study had also estimated that quarantine and other public health measures "prevented more than 2 000 additional cases" aboard the Diamond Princess, compared to doing nothing at all, Kuroda's group noted.

Possible 'superspreading'

In the new study, the Japanese team sought to determine the origins of the cruise ship outbreak. To do so, they analysed the DNA of samples of SARS-CoV-2 in nasal swab tests obtained from almost 900 passengers and crew during the outbreak.

The genetic analysis suggests "that there was a single introduction of SARS-CoV-2, which disseminated among passengers on the ship through possible mass gathering events in the recreational areas," according to the study.

The dominance in samples of coronavirus with a particular gene "cluster" also suggests possible "superspreading" onboard, long before the quarantine began, the study authors said.

The virus may have silently spread in events as innocuous as a shared dinner table or during "dancing, singing, shopping, and watching performances", Kuroda's group said.

While cruise ships may be a unique environment, the outbreak – and quarantine – aboard the Diamond Princess reveals "how SARS-CoV-2 can be spread in the community" more generally, the research team said.

Resuming operations

Dr Amesh Adalja is an infectious disease expert and senior scholar at the Johns Hopkins Center for Health Security, in Baltimore. Reading the new report, he said it "illustrates how a contagious respiratory virus can disseminate widely from just one person in the right context".

And for anyone still contemplating a cruise, the new findings show that "most of the cases may have been contracted at mass gathering events on the ship – an important factor to consider as cruise lines begin to think about resuming operations," Adalja said.

The study was published on 28 July in the Proceedings of the National Academy of Sciences.

Image credit: Getty Images