Updated 20 March 2015

Folic acid may ward off stroke in high blood pressure patients

Supplementing with folic acid, a type of B vitamin, may be the key to preventing stroke in high blood pressure patients, according to a Chinese study.


Folic acid – the same nutrient women take in pregnancy to help ward off birth defects – may also help lower stroke risk in people with high blood pressure, a new Chinese study finds.

The findings are intriguing, one U.S. heart health expert said.

"If all that is required to prevent the greatest health threat worldwide is a vitamin, then we need to consider checking patients' blood levels of folic acid and supplementing if needed," said Dr. Suzanne Steinbaum, a preventive cardiologist at Lenox Hill Hospital in New York City.

Randomly assigned to take folic acid

The new study was led by Dr. Yong Huo of Peking University First Hospital in Beijing. Huo's team tracked outcomes for more than 20,000 adults in China with high blood pressure who had not suffered a heart attack or stroke. Participants were randomly assigned to take a daily pill with folic acid and the high blood pressure drug enalapril (brand name Vasotec) or a pill with enalapril alone.

Over a median treatment period of 4.5 years, first strokes occurred in 2.7 percent of those in the enalapril/folic acid group and 3.4 percent of those in the enalapril group, the study found. That means that the risk of stroke was 21 percent lower among those taking enalapril/folic acid.

Patients taking enalapril/folic acid also had a lower risk of ischaemic stroke (2.2 percent versus 2.8 percent), specifically. Ischaemic strokes are strokes caused by a blockage, and comprise about 87 percent of all strokes, according to the American Stroke Association.

Read: Is high blood pressure bad?

Adding folic acid was also tied to a reduction in heart-related death, heart attack and stroke (3.1 percent versus 3.9 percent), the investigators found.

There were no significant differences between the two groups in the risk of bleeding stroke or death from any cause, the study authors reported.

The study was published in the Journal of the American Medical Association and was to be presented simultaneously at a meeting Sunday of the American College of Cardiology in San Diego.

Important implications

The findings have "important implications for stroke prevention worldwide", Dr. Meir Stampfer and Dr. Walter Willett, of Harvard School of Public Health in Boston, wrote in an accompanying journal editorial.

They said even though this study included people with high blood pressure, "there is little reason to doubt" that the findings would apply to people without high blood pressure.

Read: The seven steps to recovering from a stroke

For her part, Steinbaum pointed out that "low folic acid can be associated with elevated risk of heart disease and stroke." Often, an abnormality in a specific gene called MTHFR can lead to an individual having low folate levels, she said.

Stampfer and Willett said that billions of people worldwide may have low levels of folic acid, which is a B vitamin. According to the U.S.

Found naturally in fruit and veg

National Institutes of Health, folic acid is found naturally in dark leafy vegetables, dried beans and peas, and citrus fruits and juices. Many foods – such as breads, cereals and pastas – are now fortified with folic acid. The nutrient can also be taken in supplements.

Read: When is blood pressure considered high?

"Although we would hope that diet would be the best source of nutrients, sometimes it is impossible to get enough essential nutrients in our diets," Steinbaum said. "The study shows that with supplementation of folic acid, it might actually help prevent the risk of stroke."

Read More:

Aspirin 'resistance' may mean worse strokes

Love coffee? Your heart may too

Why fried foods are bad for your heart

Image: Folic acid tablets from Shutterstock


Read Health24’s Comments Policy

Comment on this story
Comments have been closed for this article.

Ask the Expert

Hypertension expert

Dr Jacomien de Villiers qualified as a specialist physician at the University of Pretoria in 1995. She worked at various clinics at the Department of Internal Medicine, Steve Biko Hospital, these include General Internal Medicine, Hypertension, Diabetes and Cardiology. She has run a private practice since 2001, as well as a consultant post at the Endocrine Clinic of Steve Biko Hospital.

Still have a question?

Get free advice from our panel of experts

The information provided does not constitute a diagnosis of your condition. You should consult a medical practitioner or other appropriate health care professional for a physical exmanication, diagnosis and formal advice. Health24 and the expert accept no responsibility or liability for any damage or personal harm you may suffer resulting from making use of this content.

* You must accept our condition

Forum Rules