baby treated for HIV within hours of birth is free of the virus nearly a
year later, in the second case that has raised hopes about early treatment,
approach mirrored that taken for a Mississippi baby, who has been off treatment
for 21 months and still has no detectable virus in her system.
latest research on the two young girls was presented at the annual Conference
on Retroviruses and Opportunistic Infections (CROI) in Boston.
Early treatment essential
newest case involves a Los Angeles baby was born to a mother infected with HIV
and who had not been taking her medications, making her at high risk for transmission,
said Yvonne Bryson, chief of paediatric infectious diseases at the David Geffen
School of Medicine at the University of California, Los Angeles.
Deveikis, a paediatric infectious disease specialist at Miller Children's
Hospital Long Beach, where the baby was born, tested the infant and gave her
high, treatment-level doses of antiretroviral
drugs before even knowing if she was HIV-positive, Bryson told AFP.
way it works is you test and you treat before you know the results because it
takes several days to get the results," explained Bryson, a consultant on
started at four hours of age, even earlier than the Mississippi child.
Eventually, the tests came back positive for HIV but by six days of age, the
virus was undetectable.
remarkable thing about this particular baby is that the virus disappeared so
quickly," said Bryson.
baby is still being treated with antiretroviral drugs, and researchers are
cautious not to utter the world "cure" or even "remission"
aged 11 months, the child is doing well and continues to see doctors while
under the care of a foster family.
has "no detectable viral load, nothing since six days of age. That is the
earliest ever," said Bryson.
she turns two, doctors may decide to stop suppressive therapy to see if she is
in remission, or if the virus would rebound.
only way we would know if the baby is in remission is to stop therapy,"
at the conference, Deborah Persaud of Johns Hopkins University presented the
latest on the Mississippi baby, who was given ART at 31 hours of age.
Considered in remission
the three-year-old is considered in remission from HIV, after drug treatment
was stopped 21 months ago and no viral rebound has been observed.
said the Los Angeles team is optimistic that their baby will do just as well.
fact that it was a very fast reduction in the virus to undetectable levels makes
us very hopeful that this baby might follow in the footsteps of the Mississippi
which is still being followed," said Bryson.
are learning a lot now and it is exciting for the future."
is no known cure for Aids, which has infected some 70 million people around the
world and killed 35 million, according to the World Health Organization.
affected by HIV/Aids
drugs halt transmission
HIV transmission linked to gene change