20 November 2008

Early treatment saves Aids babies

Sooner is better when it comes to treating infants born with the Aids virus, HIV, South African researchers reported on Wednesday.

Sooner is better when it comes to treating infants born with the Aids virus, HIV, researchers reported on Wednesday.

A South African study of 377 babies found that giving newborns drug therapy right away, and not waiting until conventional tests showed a higher risk of becoming ill, cut the death rate by 76%.

When doctors withheld therapy until there were symptoms of Aids or until immune system cells called CD4 T-cells dropped to low levels, the death rate was 16%, the researchers reported in the New England Journal of Medicine.

But among babies who began receiving treatment right away, typically around 7 weeks of age, only 4% died after about 40 weeks of care.

Study changed worldwide treatment
The leader of the study, Dr Avy Violari of the University of Witwatersrand in Johannesburg, said the results have already prompted officials in the United States, Europe and the World Health Organisation this year to recommend immediate treatment for infected babies.

Before then, doctors were advised to take an individual approach to care for infants, who are infected by their mothers during birth or while nursing.

"This was the landmark trial," Violari said in a telephone interview.

More than one-third of the deaths occurred at home, before caregivers realised something was wrong. Pneumonia and gastroenteritis were the chief causes.

"HIV attacked the developing immune system extremely quickly. The decline was so rapid, short of seeing the babies every day, you won't be able to pick up any meaningful changes that would prompt a doctor to start treatment," Violari said.

Warning signs very subtle
"The other thing is that the signs (of trouble) are so subtle, they don't give a good warning for the parent."

She said early testing for newborns is expensive and identifying infected babies will be a real challenge for developing countries.

"It's going to take a few years until early infant diagnosis is established," Violari said.

The study, known as the CHER trial, was designed to see if early HIV therapy would give the immune system time to develop and learn how to ward off the deadly illness.

The test was halted early because the results were so dramatic, and all the children who were not being treated were given HIV drugs.

2 million children infected
The Aids virus infects an estimated 33 million people globally. In 2007, 370 000 children became newly infected, and a total of 2 million are now infected with the deadly and incurable virus.

Drug cocktails can suppress the virus and keep patients healthy but they are expensive and difficult to get. There is no vaccine.

Giving the mother and baby HIV drugs around the time of birth can reduce transmission. – (Gene Emery/Reuters Health)

Read more:
HIV+ babies need drugs early
HIV/Aids Centre

November 2008


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Dr Sindisiwe van Zyl qualified at the University of Pretoria in 2005. She is a patients' rights activist and loves using social media to teach about HIV. She is in private practice in Johannesburg.

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