Screening all women for gene mutations that increase the risk of breast and ovarian cancer is too costly to be feasible, a new study suggests.
Women with BRCA1 and BRCA2 gene mutations have a much higher risk of breast and ovarian cancer than those without the mutations.
The study authors found that for every 10,000 women in the general population who were screened, about four more cases of breast cancer and two more cases of ovarian cancer would be prevented, compared with screening only women with a family history of the cancers.
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However, BRCA screening would only extend patients' lives for an average of two days, the researchers added. And for more than 99 percent of women screened, a negative genetic test would not increase life expectancy or eliminate the need for regular mammograms, and could falsely reassure women that they aren't at risk for breast cancer, the study authors said.
"The cost of BRCA testing would need to drop by 90 percent for testing to be cost-effective for the whole population," study co-author Dr. Patricia Ganz, director of the division of cancer prevention and control research at the Jonsson Comprehensive Cancer Centre at UCLA, said in a university news release.
"It's like looking for a needle in a haystack," study co-author Elisa Long, an assistant professor in the School of Management, said in the news release.
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The study was published online recently in the journal JAMA Oncology.
Of the 233,000 breast cancer cases diagnosed in the United States each year, only 5 percent to 10 percent are associated with BRCA gene mutations, according to background information in the news release.
BRCA genetic testing should be limited to women with a known family history of breast, ovarian, tubal or peritoneal cancer, according to the U.S. Preventive Services Task Force.
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Image: Breast examination from iStock