04 July 2017

This is why some type 1 diabetics still produce insulin

Swedish researchers have launched a study to see if they can boost insulin production in people with type 1 diabetes who are still making some insulin.


In type 1 diabetes, the immune system attacks the cells in the pancreas that produce insulin, the hormone that helps usher sugar to cells to be used as fuel. 

A recent Swedish study found that almost half of people with type 1 diabetes are still producing some insulin more than a decade after being diagnosed with the disease.

This challenges previous assumptions that people with type 1 diabetes lose their ability to produce any insulin over time.

Researchers at Sweden's Uppsala University, led by post-doctoral researcher Daniel Espes, reached their conclusions after studying more than 100 patients with type 1 diabetes.

The study appears in the June issue of Diabetes Care.

High levels of protein

The investigators found that people who still produced insulin despite their long-standing type 1 diabetes had higher levels of a protein called interleukin-35. This protein appears to play an important role in the immune system.

Past research had shown that both newly diagnosed people with type 1 diabetes and those who've had the disease for some time had lower average levels of interleukin-35 compared to healthy people.

Type 1 diabetes is an autoimmune disease that causes the body's immune system to mistakenly attack healthy cells in the pancreas that make insulin, causing insufficient insulin production and uncontrolled blood glucose levels in the cardiovascular system leading to various health complications.

Prevalence of diabetes

According to Health24, three-and-a-half million South Africans – about 6% of the population – suffer from diabetes – with he highest prevalence among the Indian population (11–13%), as this group has a strong genetic predisposition for diabetes, followed by 8–10% in the coloured community, 5–8% among blacks and 4% among whites.

This leaves people without enough insulin to meet the body's daily needs. To survive, people with type 1 diabetes must replace that lost insulin through multiple daily injections or through a tiny tube inserted under the skin every few days and then attached to an insulin pump.

The Uppsala researchers have launched a new study to see if they may be able to boost insulin production in those people with type 1 diabetes who are still making insulin.

Read more:

Transplant of insulin-producing cells – new hope for diabetics

Artificial Pancreas Helps Type 1 Diabetics During Sleep

Type 1 diabetes linked to gut


Ask the Expert

Diabetes expert

Dr. May currently works as a fulltime endocrinologist and has been in private practice since 2004. He has a variety of interests, predominantly obesity and diabetes, but also sees patients with osteoporosis, thyroid disorders, men's health disorders, pituitary and adrenal disorders, polycystic ovaries, and disorders of growth. He is a leading member of several obesity and diabetes societies and runs a trial centre for new drugs.

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