06 May 2010

Poor sleep bad for blood sugar

Just one sleepless night can hamper the body's ability to use insulin to process sugar in the bloodstream.

Just one sleepless night can hamper the body's ability to use insulin to process sugar in the bloodstream, according to a study which scientists say might help explain why diabetes is on the rise.

Researchers said their findings suggest it may be no coincidence that while sleep duration has shortened in western societies in the past decade, there has also been an increase in cases of "insulin resistance" and adult-onset diabetes.

"Our findings show a short night of sleep has more profound effects on metabolic regulation than previously appreciated," said Esther Donga, director of Leiden University Medical Center in the Netherlands, who led the study.

Type 2 diabetes is caused by the body's inability to adequately use insulin, a hormone produced by the pancreas, to control glucose sugar produced from food. Sugar levels rise and can damage the eyes, kidneys, nerves, heart and major arteries.

The disease, linked to poor diet and lack of exercise, is reaching epidemic levels. An estimated 180 million people now suffer from diabetes around the world.

Previous studies have found that several nights of poor sleep can result in impaired use of insulin, but Donga said this was the first study to examine the effects of only a single bad night's sleep.

Insulin sensitivity

The Dutch scientists examined nine healthy people - once after a night of eight hours sleep and once after a night of just four hours.

The findings, published in the Journal of Clinical Endocrinology & Metabolism (JCEM), showed that partial sleep restriction during a single night reduced some types of insulin sensitivity by 19% to 25%.

"Our data indicate that insulin sensitivity is not fixed in healthy (people), but depends on the duration of sleep in the preceding night," Donga wrote in the study.

"In fact it is tempting to speculate that the negative effects of multiple nights of shortened sleep on glucose tolerance can be reproduced, at least in part, by just one sleepless night."

Sleep linked to abnormal blood sugar

A study by US scientists published last year found that people who slept less than six hours a night were 4.5 times more likely to develop abnormal blood sugar readings in six years compared with those who slept longer.

Experts say adults typically need between seven and nine hours sleep a night.

Donga said further studies were needed to see whether ways of improving sleep duration could help stabilize glucose levels in patients with diabetes. - (Kate Kelland/Reuters Health, May 2010)


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Dr. May currently works as a fulltime endocrinologist and has been in private practice since 2004. He has a variety of interests, predominantly obesity and diabetes, but also sees patients with osteoporosis, thyroid disorders, men's health disorders, pituitary and adrenal disorders, polycystic ovaries, and disorders of growth. He is a leading member of several obesity and diabetes societies and runs a trial centre for new drugs.

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