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Diabetes

Question
Posted by: Pkumar | 2020/07/25

Q.

Linaglptin and metformin combo

Whether linaglptin+metformin ok with ejection fraction 35 Or may be more DM2 since 10 years with a1c 6.5 and echo 35 EF by one dr and second EF 50!!!

Expert's Reply

A.

Diabetes expert
- 2020/07/31

Hi

Metformin is safe in patients with a reduced ejection fraction, unless the heart failure is very bad(not the case here). There has been some concern with some DPP4 drugs and increasing heart failure, but when Linagliptin was tested in a big study(Carmelina), there was no increased risk of  heart failure or other associated heart failure related complications The best drug class for someone with a reduced ejection fraction though would be an SGLT2 inhibitor like empagliflozin or Dapaglifozin.  

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