Posted by: Nico Kaber | 2017/11/02


I need to replace Glucovance as it is no longer available in Gauteng, South Africa.

I am 70 years old, type II diabetes well controlled with 500/2.5 and 250/1.25 Clucovance twice daily. Glucophage not suitable as it has undesirable side effects, especially diarrhoea. Not obese, 1.77 metres tall, 96 kilogram in weight, 127 cm chest and about 8 to 10 kg overweight. Blood pressure well controlled. Tried to pick up the outstanding balance of my prescription today but no luck. The 250/1.25 has been unavailable for a month or two and the pharmacist gave me 30 of the 500/2.5 which I broke in two and used half a tablet with the 500/2.5. Would you please be as kind as to recommend a replacement that I can tell my GP about. Sincere regards

Expert's Reply


Diabetes expert
- 2017/11/03


You would need to use the metformin and glibenclamide separately, as there is no combination alternative. In the case of the glibenclamide, this would likely need to be changed to a tablet called Diaglucide MR as it is not a good option in elderly patients. I suggest talking to your doctor about the options

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user comments


Posted by: Hannes Grobler | 2017/11/14

I have the same problem in that I can get Glucovance and am now on Diaglucide and Glucophage. I'm sorry but this just doesn't work for me.. Besides the diarrhoea I feel horrid and am shaky and sweaty. My sugar HB1C has gone from 6.3 to 7.2. I think my Dr is great but he cant give me answers. Will Glucovance come back.?

Reply to Hannes Grobler

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