Glucose in the blood comes from your diet and your liver. Prednisone causes your liver to increase glucose production, which is why glucose levels can go up on cortisone. In terms of your question, I can't really answer it, as I don't know what your diet is like, whether your medication is adequate, or how much the prednisone is increasing your glucose levels. If you had well controlled glucose levels prior to the prednisone, and then the levels went up, then it is likely the prednisone
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