Type 2 diabetes patients with dangerously low blood sugar levels may be at increased risk for cardiovascular disease, according to a new study.
Given their findings, "less stringent glycaemic targets may be considered for type 2 diabetic patients at high risk of hypoglycemia (severely low blood sugar)," the researchers said.
A dangerously low blood sugar level often is classified as a medical emergency. Previous observational studies have reported a link between severe hypoglycaemia and cardiovascular disease risk, but the association remains controversial.
In this study, researchers from the United States, Japan and the Netherlands analyzed the findings of six studies that included a total of more than 903 000 type 2 diabetes patients.
The review revealed that 0.6% to 5.8% of patients developed severe hypoglycaemia during one to five years of follow-up. Overall, these patients had a 1.56% increased risk of developing cardiovascular disease, according to the study, which was published July 30 in the online journal BMJ.com.
The results suggest that severe hypoglycaemia is associated with a two-fold increased risk of cardiovascular disease, the researchers said.
Because of this, preventing severe hypoglycaemia in people with type 2 diabetes may be important to prevent cardiovascular disease, the researchers said in a journal news release.
The link between severe hypoglycaemia and increased cardiovascular disease risk has previously been explained by patients with one or more other serious illnesses, but this is an unlikely explanation, the researchers said.
They said the incidence of serious illnesses would need to be "unrealistically high" among patients who developed severe hypoglycaemia, and the link between serious illnesses and cardiovascular disease would have to be "extremely strong".
The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about diabetes, heart disease and stroke.