Posted by: | 2019/12/10



Hi there Please could you kindly advise Is Naltrexone ok to take at night? 50mg. It makes me feel terrible during the day and exhausted. Would it be safe to take with 300mg of serequel? I am taking it for cravings. Thank you

Expert's Reply


Depression expert
- 2019/12/12

Both these drugs are not used to treat substance abuse, sometimes alcohol or opioids.  If so I would expect any doctor treating you and providing these prescriptions, to have discussed risks and benefits with you, and to have specifically advised you on drug interactions and timing of dosage : and I gather some doctors advise different timings of the drugs depending on the dose being used.  So the best advice I can give you is to discuss this with your prescribing doctor.
This is not a combination I myself have used with my patients ; but I understand that time of daily dose may not be very important though a general rule we use is if side-effects are troubling, and these can include drowsiness,  it may be more comfortable to take the dose at night.
The combination of Naltrexone and Seroquel seems to be used and considered relatively safe from serious interactions : again, your doctor should be very familiar with this combination if he recommends it, and would not have done so unless he was confident that the combination is safe.

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