Posted by: Pam | 2018/05/23


I have been on Cymbalta for almost a year and a half with no side effects and it worked wonders for me. All of a sudden the last month I feel as is if it quit working or something.

I feel hateful and anxious and I feel as if I cannot get along with anyone my co workers my family anyone. Its really getting bad to the point I am about over it all.. please help.. thank you

Expert's Reply


Depression expert
- 2018/05/24

Hello Pam,
Hmm.  So you are still on the same dose of Cymbalta that you have been taking for 18 months ?  Usually when such a drug works and is helpful, it doesn't usually just stop working.  Has anything else changed in your life or the meds you take ?  Have you started drinking more alcohol than usual ? ( alcohol can damage and reduce the effects of antidepressants. )
Do discuss this change with the doctor treating you and who provides the prescriptions. Do not suddenly and abruptly stop taking the drug, as this can in itself cause unpleasant side-effects ; such drugs need to be reduced gradually.
Also, considering the interpersonal problems you've run into, consider arranging to see a counselor to talk through and change that

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