Sorry to hear about this. You don't mention whether you're being treated by a GP or a psychiatrist : in my view, when the initial treatment in general practice, for a depression / anxiety or bipolar disorder is not working well, one should consult a specialist psychiatrist for a second opinion and a fresh assessment and review of treatment options.
In a situation such as you describe, there needs to be a full-scale review of your diagnoses, previous treatments, and available alternatives, which should include consideration of adding effective non-drug treatments such as CBT ( Cognitive-Behaviour Therapy ).
I would also be cautious about recommending one of the sedative tranquillizers like Tranquipam for more than a couple of months, due to the potential for developing dependence on it. As I'm sure your doctor will also advise you, it is important with all such drugs, to stop them gradually and not abruptly, as there can be unpleasant withdrawal effects otherwise.
It should be practical to fin a combination of treatments that should help you to feel much better before long.
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