Three patients treated with an experimental Bristol-Myers Squibb Alzheimer's drug have developed vasogenic edema, but the side effect may be common in Alzheimer's patients, US researchers said.
But while previous cases of swelling were seen in drugs that use antibodies to remove beta-amyloid plaques from the brain, the Bristol drug BMS-708163 is a gamma-secretase inhibitor that targets the disease with a different mechanism.
Side effects maybe more common than thought
"No one had thought this was likely in a trial of a gamma-secretase inhibitor," Dr Reisa Sperling of Harvard Medical School and Massachusetts General Hospital in Boston told the meeting. She added that the presence of the effect in different classes of drugs showed the side effect may be more common than previously thought.