Cervical Cancer

11 March 2009

Over 20? HPV shot not worth it

An expensive vaccine aimed at preventing cervical cancer makes sense for young teens when it comes to cost-effectiveness, but not for women in their 20s, contends a new report.

An expensive vaccine aimed at preventing cervical cancer makes sense for young teens when it comes to cost-effectiveness, but not for women in their 20s, contends a new report.

The vaccine against the human papillomavirus (HPV) was approved by the Medical Control Council earlier this year for use in girls and women ages 9 to 26. Health officials recommend it for girls at age 11 or 12, and some doctors offer it to women in their 20s in "catch-up" vaccination campaigns.

In the US, the maker of the Gardasil vaccine, Merck & Co., also wants to market it to women ages 27 to 45, but so far the US Food and Drug Administration has denied that request.

Value for over-20's uncertain
A US government-funded study found the HPV vaccine is very cost-effective when given to girls at age 12, but raises questions about the value of pushing for vaccinating adults.

Two researchers at the Harvard School of Public Health did the study, one of the most sophisticated analyses of the issue so far. Results were published in a recent copy of the New England Journal of Medicine.

Gardasil is given in three doses over six months and costs in the region of R3 000. It targets the two types of HPV responsible for about 70 percent of cervical cancer cases, and two other types that cause genital warts. The virus spreads through skin-to-skin contact, usually during sex.

Health officials say it's best to give the shots to girls at age 11 or 12, before they begin having sex. Some parents think that age is too young for a vaccination campaign against a sexually transmitted disease.

But that is when the shots make the most economic sense, the researchers found.

They used computer models to predict the health outcomes of girls and women who get the vaccination as well as Pap tests or other screenings, which are still recommended for vaccine recipients. Their calculation included the cost of the vaccine, screenings and treating cervical cancer and other illnesses targeted by the vaccine.

How much is a life worth?
To determine cost-effectiveness, the researchers used widely accepted economic measures of how much society is willing to pay to extend the life of a person by a year. They set a figure of $43 600 (R338 073) per year for the Gardasil vaccination of each 12-year-old girl, well below the $100 000 (R775 397) mark seen as an upper range for cost-effectiveness.

That assumes the vaccine gives lifetime protection – something doctors don't know is true, because the shot is too new.

"Their base-case assumptions are quite optimistic," wrote Dr Charlotte Haug, a Norwegian physician, in an editorial that accompanies the study.

The figure would rise if a booster shot is needed, but would still be under the cost-effective threshold, experts said. Another caveat: Costs could rise if there is an increase in the types of cancer-causing HPV not included in the vaccine.

Vaccinating "catch-up" campaigns for women in their 20's, however, would not be cost-effective, the researchers said. They didn't calculate cost-effectiveness of vaccinating women ages 27 to 45, but a trend seems clear, said Jane Kim, the study's lead author.

"As you get older, the vaccine becomes less cost-effective," she said.

Less exposure at a younger age
Experts believe that the earlier a female is vaccinated, the better the odds she will avoid HPV-caused cervical disease, thus lowering health-care costs down the road.

Even though Merck can't promote its use for them, women older than 26 can get the shot from their doctors, as part of an "off-label" use. An individual woman may decide that getting vaccinated is worth it even if vaccinating everyone her age isn't considered cost-effective, some policy experts noted.

Many women in their 30s and 40s have not been exposed to the HPV types in the vaccine and could benefit from the shots, said Dr Richard Haupt, Merck's executive director for Gardasil research. – (Mike Stobbe/Sapa-AP, August 2008)

Read more:
Cervical cancer vaccine
New HPV vaccine launched in SA


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