17 June 2019

Testicular cancer treatment unlikely to trigger birth defects

A Swedish study found a slightly raised risk to children of fathers who had testicular cancer, but this was only very small and was not associated with treatment given.

New research should reassure dads-to-be who've had testicular cancer that treatment with radiation or chemotherapy doesn't raise the risk of fathering babies with birth defects.

"Our research set out to investigate whether treatment for the most common cancer among young men leads to a higher risk of fathering a child with a birth defect and we saw no increased risk associated with cancer therapies," said lead researcher Yahia Al-Jebari, of Lund University in Sweden.

The report was published online in the journal PLOS Medicine.

Slightly greater risk

Testicular cancer treatment has raised concerns because radiation and chemotherapy can cause genetic damage to sperm. Some people theorised that this damage might increase the risk for birth defects.

For the study, Al-Jebari and colleagues followed more than 4 200 children born to nearly 2 400 fathers between 1994 and 2014, in Sweden.

Children conceived after the father had been treated for testicular cancer had a slightly greater risk of birth defects than those conceived before the treatment, the investigators found.

Not a cause for concern

But the risk was small – about four children in every 100 – which shouldn't worry parents, the study authors said.

"We did see a slightly raised risk to children of these fathers, but this was only very small and was not associated with treatment given.

"Patients should be reassured that this is not a cause for concern," Al-Jebari said in a journal news release.

The findings are limited by the lack of data on frozen or donor sperm.

Also, not many patients were treated with radiation and high doses of chemotherapy, the authors noted.

Image credit: iStock


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