Updated 08 December 2016

Breast cancer prevention drug no use beyond 5 years

A study of older breast cancer survivors indicated that taking anti-oestrogen drugs for more than the recommended five years did not help them live longer.


Many breast cancer survivors take anti-oestrogen drugs for at least five years to help lessen their risk of recurrence.

Case-by-case basis

Now, new research suggests that taking such a drug for an even longer period might not confer any added benefit, at least in terms of survival.

The study of thousands of older breast cancer survivors found that taking the aromatase inhibitor drug letrozole (Femara) for more than the recommended five years did not help them live longer.

However, other benefits were noted, so the decision to extend use of drugs like these is one best made on a case-by-case basis, cancer specialists said.

One oncologist who reviewed the new findings said the study has been "eagerly awaited", since many breast cancer survivors are counselled to take an aromatase inhibitor.

Read: Decoding breast cancer

"For now, this trial reinforces the need to listen to our patients and weigh out the risk of side effects before extending therapy to 10 years," said Dr Nina D'Abreo, medical director of the Breast Health Programme at Winthrop-University Hospital in Mineola, New York.

Many forms of breast cancer may grow in the presence of oestrogen, so medicines such as oestrogen-suppressing aromatase inhibitors are used to help prevent the disease.

Some other benefits

But how long should breast cancer survivors be placed on such drugs?

To help find out, researchers tracked outcomes for almost 4,000 postmenopausal women with early stage hormone receptor-positive breast cancer (meaning the tumours were sensitive to oestrogen). The women took either letrozole or a placebo for an average of about two years after an initial five years of aromatase inhibitor therapy.

The result: Women who took letrozole for those extra two years did not experience statistically significant higher rates of either "disease-free" survival or overall survival than those in the placebo group, the study found.

There were some other benefits, however. For example, women who extended their use of letrozole showed a 29 percent reduction in breast cancer recurrence, and a 28 percent reduction in a tumours arising at locations outside the breasts.

Read: Vitamin D levels may affect breast cancer survival

The study was led by Dr Terry Mamounas, medical director of the Comprehensive Breast Programme at University of Florida Health Cancer Centre in Orlando. He presented the results at the annual San Antonio Breast Cancer Symposium in Texas.

Women who took letrozole for the additional years also experienced a "small increase in the risk of [clotting] events after 2.5 years," Mamounas noted in a meeting news release. This slight uptick in cardiovascular risk means that older women considering extra time on the drug "will require careful assessment of potential risks and benefits", he said.

Individualised for each patient

This case-by-case assessment would involve a discussion of various patient factors, such as the patient's age at diagnosis, whether cancer had spread to lymph nodes, other illnesses the patient might have, her bone mineral density, and the side effects she had experienced from the aromatase inhibitor drug, Mamounas said.

For her part, D'Abreo agreed that any decision on whether to take an aromatase inhibitor beyond five years is best made on a case-by-case basis.

"For some subgroups of women with 'high risk' disease, this may be worth the side effects," she said. "Hormone-positive cancers may still recur much later and for our patients who are living longer, healthier lives, there may be benefits of extended therapy beyond the seven-year period of observation on this trial."

Read: Less intrusive breast cancer treatment can save many lives

Dr Ruby Sharma is a medical oncologist at Northwell Health Cancer Institute in Lake Success, New York. She agreed that based on the findings, "the decision to prescribe additional five years of endocrine therapy needs to be individualised for each particular patient depending on individual risk of recurrence and side effects of treatment."

The study was funded by the US National Cancer Institute and the drug company Novartis, which makes Femara.

Experts note that findings presented at medical meetings are typically considered preliminary until published in a peer-reviewed journal.

Read more:

Diagnosing breast cancer

Antiperspirants and breast cancer

Breast cancer and intimacy


Ask the Expert

Cancer expert

CANSA’s purpose is to lead the fight against cancer in South Africa. Its mission is to be the preferred non-profit organisation that enables research, educates the public and provides support to all people affected by cancer. Questions are answered by CANSA’s Head of Health Professor Michael Herbst. For more information, visit

Still have a question?

Get free advice from our panel of experts

The information provided does not constitute a diagnosis of your condition. You should consult a medical practitioner or other appropriate health care professional for a physical exmanication, diagnosis and formal advice. Health24 and the expert accept no responsibility or liability for any damage or personal harm you may suffer resulting from making use of this content.

* You must accept our condition

Forum Rules