Scientists close in on molecular moves that let tumour cells act as stowaways in lymphatic system.
"In many carcinomas, lymphatic vessels grow and remodel around and sometimes within tumours. This allows tumour cells to go upstream to the lymph nodes," explains assistant professor Mark Fuster, who led the study. Once tumour cells hitch a ride to the lymph nodes, the disease can be more difficult to fight. "We were trying to understand the mechanisms that turn on the growth of lymphatic vessel cells in the laboratory."