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Cancer

Question
Posted by: Darp | 2019/11/16

Q.

Medical literature has contradictory info on whether L-Arginine/NO causes or prevents cancer

The question have today is have noticed a conflict in the literature on whether L-Arginine is preventative or causative for cancer and can not find this issue being addressed. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248324/ Recent evidence indicates that most of the cytotoxicity attributed to NO is rather due to peroxynitrite, produced from the diffusion-controlled reaction between NO and another free radical, the superoxide anion. Peroxynitrite interacts with lipids, DNA, and proteins via direct oxidative reactions or via indirect, radical-mediated mechanisms. These reactions trigger cellular responses ranging from subtle modulations of cell signaling to overwhelming oxidative injury, committing cells to necrosis or apoptosis. versus: https://www.tandfonline.com/doi/abs/10.1080/01635581.2018.1490782 Effects of Watermelon Powder and l-arginine Supplementation on Azoxymethane-Induced Colon Carcinogenesis in Rats "Research suggests that increased NO levels have tumoricidal effects." That is just two examples, but there are dozens saying the opposite on both sides, yet each side never mentioning the other side which seems strange. Most interested in having an expert comment on this conflict. Is it possible that NO being cancer causative is in just certain areas of body where L-Arginine does not cause NO?

Expert's Reply

A.

Cancer expert
- 2019/11/20

Dear Darp
Thank you for your comments. It has been said by many scientists, oncologists and others that there is no one single cause for cancer. Scientists believe that it is the interaction of many factors together that eventually produce cancer. (MCH).



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