Since Paget’s disease of the nipple is essentially a diagnosis of breast cancer per se the treatment is the same as that for any other form of breast cancer which has been diagnosed early enough for surgery.
The location of any cancer within the breast will determine the type of surgery.
If the cancer is non-invasive, that is, DCIS, then a lumpectomy, followed by radiotherapy may be performed.
If the cancer is far from the nipple, then a mastectomy may be needed to remove the breast lump and the entire nipple.
Drug therapy may be necessary after the mastectomy.