Breast cancer

26 March 2008

Scientist puts cancer to sleep

Highly aggressive breast cancers might in future be "put to sleep" rather than attacked with chemotherapy, research from an Australian scientist suggests.

Highly aggressive breast cancers might in future be "put to sleep" rather than attacked with chemotherapy, research from an Australian scientist suggests.

Dr Alex Swarbrick of Sydney's Garvan Institute said the research, conducted in collaboration with US-based Nobel prize winning Professor J. Michael Bishop, found that a gene called Id1 drives some breast cancers.

But by switching the gene on and off, it was possible to either encourage or shrink tumours.

How the research was done
In experiments with mice, Swarbrick found that by stimulating the gene he could create tumours. Moreover, mammary cancers with high levels of the gene became very aggressive and were likely to spread to the rest of the body.

"We also showed that if we genetically switch off the Id1 gene in an established tumour, those mice live much longer than mice with continual Id1 expression in their tumour," he said.

"In fact, about 40 percent of them were cured and the tumours just shrank away."

Swarbrick said the findings, published online in the US journal of the Proceedings of the National Academy of Sciences, suggested that as well as trying to kill cancer cells, doctors could also try to put breast tumours to sleep.

What the findings mean
"Many cancers mutate the genes involved in cell death, so it's hard to kill them," he said.

The research results suggested that by therapeutically targeting genes which could switch off the cancers, such as Id1, tumours could be put to sleep, he said.

"You induce a terminal sleep, and then the immune system just gobbles them up," he said.

Swarbrick began his research three years ago while working as a post-doctoral researcher at Bishop's laboratory at the University of California San Francisco but analysed the data and tissue samples at Garvan. – (Sapa)

March 2008

Read more:
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Master breast cancer gene found


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Breast cancer expert

Dr Gudgeon qualified in Birmingham, England, in 1968. She has more than 40 years experience in oncology, and in 1994 she founded her practice, Cape Breast Care, where she treats benign and malignant breast cancers. Dr Boeddinghaus obtained her qualification at UCT Medical School in 1994 and her MRCP in London in 1998. She has worked extensively in the field of oncology and has a special interest in the hormonal management of breast cancer. She now works with Dr Gudgeon at Cape Breast Care. Read more.

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