23 October 2009

Neurotic? It could lead to asthma

People who are neurotic - they tend to worry a lot and to have emotional ups and downs - seem to be at increased risk of developing asthma, a new study hints.

People who are neurotic - they tend to worry a lot and to have emotional ups and downs - seem to be at increased risk of developing asthma, a new study hints. Those who suffer through a divorce or other relationship conflict are also at risk for asthma, according to the study.

Animal studies have shown that chronic stress alters hormone levels, which can inflame airways making it difficult to breathe. Researchers believe that neurotic character traits may exert similar effects. If so, then helping neurotic people to calm down or "chill out" could, theoretically, reduce their risk of asthma.

Dr Adrian Loerbroks from Heidelberg University, Germany and colleagues explored associations between neuroticism, stressful life events and asthma by surveying a sample of 5,114 men and women aged 40 to 65 years from Heidelberg and its surroundings.

Asthma and unemployment
Right from the start, they noticed a link between asthma and neuroticism in men, and between asthma and unemployment in both sexes. In women, having broken off a life relationship was associated with having asthma.

Among the 4,520 individuals reported to be free of asthma at the start of the study, 63 or about 2%, developed asthma during a median follow-up of more than eight years, they report in the journal Allergy.

According to the investigators, individuals who were highly neurotic were three times more likely to develop asthma than those who were less neurotic, and breaking off a life partnership increased the risk of asthma development by more than twofold.

Influence of sex
The link between high neuroticism and the development of asthma was present in women and men, whereas breaking off a life relationship increased asthma risk only in women.

Unemployment and death of a close person were not significantly associated with the development of asthma, the researchers note.

The researchers call for more study on personality traits, stress and asthma.

"The physiological mechanisms by which personality, stress, and emotions might influence the development or course of asthma," they note, "are still not well known". - (Reuters Health, October 2009)

Source: Allergy, October 2009.

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Asthma Centre


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Professor Keertan Dheda has received of several prestigious awards including the 2014 Oppenheimer Award, and has published over 160 peer-reviewed papers and holds 3 patents related to new TB diagnostic or infection control technologies. He serves on the editorial board of the journals PLoS One, the International Journal of Tuberculosis and Lung Disease, American Journal of Respiratory and Critical Medicine, Lancet Respiratory Diseases and Nature Scientific Reports, amongst others.Read his full biography at the University of Cape Town Lung Institute

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