Firstly, it's unclear how old your wife and what her diagnosis is? Does she have asthma or COPD? The tightness of the chest would be due to airways disease. If this is asthma, then the prognosis is good and there is a high success rate with optimising her condition such that she can live a normal life with good exercise tolerance. The prognosis with COPD is more guarded. I suggest you see a pulmonologist to work out exactly what she has.
The soreness is not a symptom of asthma or COPD, but could easily be related to the constant and severe coughing. A pulmonologist can also advise on a nebuliser. It is rarely helpful over and above what can be delivered via an inhaler.
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