Updated 18 January 2017

Smoking may slow arthritis

In people with rheumatoid arthritis, heavy cigarette smoking appears to slow the rate of joint destruction, new research suggests.

"Potentially, this may be due to the anti-inflammatory properties of nicotine," Dr Axel Finckh, University Hospital of Geneva, Switzerland told Reuters Health.

Cigarette smoking is a known risk factor for rheumatoid arthritis, a chronic inflammatory disease that causes progressive joint destruction, disability and premature death, Finckh and colleagues reported in the Annals of the Rheumatic Diseases.

Yet, it remains unclear if smoking influences the progressive joint destruction and disability caused by rheumatoid arthritis. Finckh and colleagues therefore assessed joint X-rays and results from self-reported functional disability questionnaires for more than 2 000 rheumatoid arthritis patients in their early- to mid-fifties.

Most of the patients (1 459) did not smoke; 489 were considered moderate smokers and 55 were classified as heavy smokers, consuming more than one pack per day.

Overall, the investigators found that the smokers and non-smokers had similar rates of progressive joint damage and functional disability.

Unexpected findings

Unexpectedly, they also found slower rates of progressive joint damage in the X-rays of heavy cigarette smokers compared with the moderate smokers and the non-smokers over the three-year study.

These findings suggest that smoking is more influential in the development of rheumatoid arthritis than the progression of the disease over time, but further research is needed to fully understand the impact smoking has on disease progression.

Still, Finckh cautioned: "The cardiovascular hazards of smoking certainly outweigh the potential anti-inflammatory benefits of nicotine," so the health risks associated with smoking are much greater than any benefits people with rheumatoid arthritis may gain from smoking.

Additional study is needed to understand the influence of tobacco and nicotine on the body's immune system.

SOURCE: Annals of the Rheumatic Diseases, July 2007.

Read more:

Stop smoking Centre

Joint pain/Arthritis Centre


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Professor Asgar Ali Kalla completed his MBChB (Bachelor of Medicine and Bachelor of Surgery) degree in 1975 at the University of Cape Town and his FRCP in 2003 in London. Professor Ali Kalla is the Isaac Albow Chair of Rheumatology at the University of Cape Town and also the Head of Division of Rheumatology at Groote Schuur Hospital. He has participated in a number of clinical trials for rheumatology and is active in community outreach. Prof Ali Kalla is an expert in Arthritis for Health24.

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