FORGET EVERYTHING YOU THOUGHT YOU KNEW ABOUT DRUGS
Drugs may make you feel great, but the crippling damage they cause to the brain has remained unseen - until now. For the first time scans have shown exactly how these substances mutilate our minds - while psychiatrists deal with the fall-out
By David Moseley and the Health24 team
FROM the height of ecstasy to the depths of hell. As quick as a flash. Then brain damage for the rest of your life. This is what the latest street drugs can do to you.
And even after you’ve stopped, these drugs can scorch the delicate tissue of your brain and change you into a monster capable of the most horrifying acts of violence. Or leave you in a dark well of depression, from which nothing will be able to save you.
It doesn’t matter which drug you try, even if it’s only once – you have to know you’re playing with fire. The stuff you’re smoking, sniffing or shooting up is going to hit your brain with the force of a lightning bolt.
It’s not the moral custodians, teachers and religious ministers who say so. It’s hardened policemen, chemical scientists and psychiatrists who are witnessing the effects of these drugs with bewilderment.
Forget everything you thought you knew about drugs. Nothing can prepare you for the havoc now caused by charlie and crystal, hot ice, china white and liquid ecstasy.
And it’s not happening somewhere else, it’s happening here in our neighbourhoods, schools and universities, to normal teenagers who “just wanna have fun” and adults who should know better.
It makes the drugged-hippie era look like a Sunday school picnic. Modern drugs are so much more powerful, so much more intense, taking you to ecstatic peaks of euphoria and energy – then dropping you into the depths of despair. No wonder it’s called a crash.
Until recently no one knew the extent of the devastation caused in your brain by this chemical violence. Now we’re beginning to find out. And it’s not a pretty sight.
- Midwives are holding babies born with their intestines outside their bodies.
- Policemen are handling the victims of merciless crimes.
- Neurologists, with the help of the latest technology, are assessing the extent of the brain damage being caused (see page 45).
If you think this is bad you should prepare yourself for the next drug wave about to hit the country, says superintendent Casper Venter of the SAPS forensic laboratories.
There’s the drug called yellow honey, a deadly new form of marijuana that is seven times stronger than normal dagga and can cause a brain meltdown. This drug surfaced in Los Angeles recently. The SAPS Narcotics Bureau predicts it will gain a foothold in South Africa soon and will make the tik problem look like child’s play.
Many local drugs have an added danger – when they’re manufactured in someone’s loo, kitchen or warehouse, you have no idea what they really contain. Street drugs are often cut with highly addictive heroin to ensure you become physically dependent. On top of that street drugs can be sold in hugely concentrated form; sometimes they are up to 1 500 times more powerful than the dose the human body can safely handle. It’s like pouring jet fuel into an old jalopy.
Street drugs may also contain harmful impurities. For example, a chemical in mandrax tablets can cause lung cancer. In the wake of drug use follow the crimes associated with it.
Violent crime in the Western Cape has increased enormously and is attributed to the dramatic rise in the use of tik. “We’re seeing more and more that when people are murdered, they’re not stabbed or shot once or twice, but as many as 60 times.
Tik changes the brain chemistry and numbs the reactions of users. Killing or raping someone is nothing to them,’’ says Venter.
The nine most common street drugs
The substances discussed here are illegal and are listed in the South
African Drugs and Drug Trafficking Act, Act 140/92.
The most common street drugs abused in South Africa are classified
according to their effect on the brain. There are three main classes:
uppers (stimulants), downers (depressants) and hallucinogens
(which cause you to see strange things).
UPPERS (STIMULANTS)
Uppers include cocaine, crack, Ecstasy, tik, crystal meth or methamphetamine,
amphetamines, ephedrine and khat.
These substances stimulate the brain and increase the heart rate. Young
people use them to feel stronger, more energetic and more decisive.
Typical signs of stimulant use are a reduced appetite, high energy levels,
insomnia, dilated pupils, talkativeness, irritability, anxiety, increased excitability
and hyperactivity, abrupt mood changes, impatience and nervousness.
1. Cocaine
Street names: blow, charlie, coke
This mind-altering drug,
extracted from the coca
bush in Peru, Bolivia
and other mountainous
countries, was once the
glamour drug of the rich
and famous but now more
and more children are
experimenting with it.
The heaven:
A feeling of exhilaration,
euphoria, hyperactivity, self-confidence,
heightened awareness and boundless
energy. The rush takes place five to
10 minutes after snorting cocaine.
The hell:
Some users will experience headaches,
tremors, apprehension and insomnia
after a single dose. Larger doses may lead
to teeth grinding and compulsive acts such
as scratching and finger tapping. Users
may hear voices and suffer from extreme
paranoia, extreme anxiety, irrational ideas
and aggression.
An overdose can result in a seizure,
panic attack, cardiac arrest, stroke, difficulty
breathing and death.
Effects on the body:
Your pulse rate
increases, your blood pressure rises and
your pupils dilate. After long-term use you’ll
look emaciated, your sex drive will decrease,
your nose will always be running and you’ll
get frequent colds. Cocaine is psychologically
and physically addictive. Once the
high wears off, addicts are left craving more
stimulation.
Effects on the brain:
Cocaine interferes
with the natural secretion of dopamine and
serotonin, two of the brain’s chemical messengers
that transmit feel-good sensations.
As a result, these neurotransmitters accumulate
and trigger the trademark “high”.
The scary fact is cocaine eventually depletes the level of neurotransmitters to such an extent that depression, apathy, fatigue, anxiety and suicidal depression can set in and may last for months.
If the depletion is total and permanent even the best antidepressants will be futile and the user may never be able to escape from the darkest depression. Some also develop Parkinson’s disease which leaves them with a tremor at an early age.
2. Crack
Street names: rocks, freebase
Crack is a cheap and deadly form of cocaine, turned
into smokeable ‘’rocks’’ with the use of additives.
Crack is coke intensified and kicking a crack habit
is three times as difficult.
The heaven:
Feelings of wellbeing, mental
exhilaration and euphoria. The high is intense but
lasts little over 10 minutes.
The hell:
The euphoric feeling is quickly followed
by devastating depression equal in intensity, creating
the need to smoke again and again. This cycle
of highs and lows causes an addiction that takes
hold faster than with any other drug.
Effects on the body:
The same as for cocaine
but intensified. Users may see snowlights or halos.
Their heart rate may become irregular, increasing
the risk of a heart attack.
Effects on the brain:
Because it’s smoked it
delivers a high dose of the drug to the brain in less
than 10 seconds – with a potency five to 10 times
greater than snorted cocaine. The assault on the brain
is quicker and more profound. It alters the biochemical
state of the brain by changing the dopamine and
serotonin receptors and depleting the stores of these
two feel-good neurotransmitters. This damage can
be permanent, leading to severe paranoia, lasting
suicidal depression or murderous rage.
3. Ice
(CRYSTAL METHAMPHETAMINE)
Street names: crystals, crystal, meth, rock, candy, batu, glass, LA glass, super ice, hot ice, LA crystal, Hawaiian salt
This newer and deadlier form of crystallised methamphetamine
is nearly 100 per cent pure methamphetamine.
Odourless and smoked in glass
pipes, it is more lethal than crack and cocaine, and
seemingly more addictive.
The heaven:
Within seconds smokers feel an
intense wave of physical and mental exhilaration. The
effects may last from four to 14 hours.
The hell:
Intense feelings of anxiety, depression,
sleeplessness and fatigue, and eventually psychosis.
Toxic psychosis similar to paranoid schizophrenia can
also result from heavy short- or long-term use.
Effects on the body:
Users need ever-heavier
doses to reach the same high. Prolonged use damages
the lungs, liver and kidneys.
Effects on the brain:
Brain damage as with tik,
but to a greater degree.
4. Ecstasy
Street names: XTC, e, Adam, MDMA
Ecstasy is a rave or party drug and is
often taken to enable the user to dance
through the night. It’s knocked together
like tik.Why does it have such a coolsounding
name? Because pronouncing
methylenedioxymethamphetamine
(MDMA) would leave most drug users
utterly perplexed.
The heaven:
There’s an enhanced sense
of pleasure, increased self-confidence and
loads of energy, peacefulness, acceptance
and empathy. The high lasts between four
and six hours.
The hell:
Users may develop blurred vision,
sweat a lot, clench their teeth or bite the
inside of their cheeks and suffer seizures,
nausea and vomiting. Used regularly for
a long time or in large doses it can change
you into an extremely depressed and paranoid
person who suffers from panic attacks.
Effects on the body:
Even in small doses
Ecstasy can be dangerous to people with
heart disease and asthma. Large doses can
lead to overheating of the body and brain,
dehydration, water retention, stroke and
heart attack.
Effects on the brain:
Ecstasy affects your
brain by increasing the release and activity
of at least three neurotransmitters (serotonin,
dopamine and norepinephrine), and
when it depletes these stores, especially
the serotonin stores, it can lead to chronic
depression. Psychiatrists say they are experiencing
an increase in psychotic episodes
and permanent brain damage among
Ecstasy users.
DANGER: Many knocked-together street drugs are sold as heroin or cocaine substitutes to naive or desperate users under the misleading name of designer drugs. Chances of an overdose are high because you don’t know what you’re buying.
5. Methamphetamine
Street names: tik, tik-tik, crystal, meth, crystal meth, crank, uppers, speed
Tik is also a knocked-together drug and
is sold in the form of powders, pills and
capsules that are sniffed, smoked or injected.
It can be manufactured at home
from medicines that are available over
the counter.
The heaven:
Like cocaine and crack, tik
leads to increased alertness, energy and
self-confidence, a heightened sense of
sexuality and euphoria.
The hell:
Aggression, violence, psychotic
behaviour, memory loss and heart and brain
damage. Long-term users face insomnia,
psychotic episodes, paranoia, hallucinations
and collapse.
Effects on the body:
Trembling hands,
increased heart rate and sweating. An overdose
can result in stroke and heart failure.
Long-term use leads to an increased risk of
hepatitis C and HIV as the drug is injected
and often prompts risky sexual behaviour.
Effects on the brain:
Tik acts as a stimulant,
similar to cocaine – but stays in the
system for longer. The exhaustion of the
brain’s dopamine supply is extremely worrying.
A tik addict loses up to half his dopamine
supply every two years, compared
with the five to 10 per cent every 10 years
for the average person. Dopamine helps
to regulate coordinated movement and as
soon as its levels drop by 15 per cent, the
victim develops Parkinson’s disease, characterised
by head and hand tremors.
In the Western Cape there are already young tik users who have Parkinson’s. Psychiatrists are also worried about the increase in cases of schizophrenia and psychosis among tik users. It seems as if tik damages the human brain to such an extent that users start acting like extremely aggressive psychopaths. This is reflected by the Narcotics Bureau’s observation that murders and rapes by tik abusers are becoming a lot more senseless and aggressive. Babies born to moms who used tik during pregnancy have a greater risk of developing Parkinson’s disease in their childhood years. Much worse: the birth of babies with intestines developed outside their tiny bodies is a regular occurrence at some Cape Peninsula hospitals.
DOWNERS (DEPRESSANTS)
These suppress or delay certain brain functions. Depending on which part of the brain
is being suppressed, they are divided into sub-groups: either narcotic or tranquillising
substances such as heroin or substances that make you sleepy such as mandrax.
6. Heroin
Street names: smack, mud, china white, brown, Mexican brown, brown sugar, gear, H, horse, junk
Heroin is produced from the resin of the
opium poppy and is the most dangerous and
addictive narcotic. Pure heroin is a white,
odourless crystalline-like powder with a bitter
taste. The browner the colour, the more
impurities it contains. It is often diluted with
starch, sugars such as glucose, powdered
milk, baby powder, washing powder, strychnine
or other poisons before being sold. It is
smoked, snorted or injected.
The heaven:
A profound sense of warmth and
wellbeing envelops the user and blocks feelings
of pain and insecurity.
The hell
Within six to eight
hours symptoms such as nausea,
vomiting, chills, excessive sweating
and muscle and bone pain
may follow.
The real hell starts with the
withdrawal symptoms which
can set in within two days after the last fix. (Read
our book extract on page 117.)
Effects on the body:
First it leads to suppression
of pain, drowsiness, heaviness of the limbs,
shallow breathing, a weak pulse, dry mouth and
pinpoint pupils. Long-term use causes liver damage,
poisoning as a result of additives, bacterial
infections, abscesses, arthritis and infection of
the heart lining and valves.
High dosages can result in a seizure, coma
and death. Babies born to mothers who abuse
heroin during their pregnancy may be born
addicted.
Effects on the brain:
Heroin is quickly changed
to morphine in the brain, which acts on certain
receptors to give that feeling of utter bliss. But
the brain reacts by creating fewer of its own
feel-good endorphins. Heroin destroys the
chemical balance in the brain
to such an extent that the
user starts to experience pain
in the absence of any injuries.
Rapid mood changes and
confusion are the result of the
chemical changes in the brain.
7. Mandrax
Street names: whites, buttons
South Africa has the highest per capita
mandrax abuse in the world. Mandrax
(methaqualone) tablets are usually
powdered and smoked with a mixture of
cannabis or tobacco in a bottleneck pipe
called a “white pipe” or “witwyf”.
The heaven:
You feel totally laid back,
at peace and without a care in the world.
You’re giving the world the proverbial
finger.
The hell:
Take too much of it and you’ll
feel nauseous, lose consciousness or fall
into a stupor.
Effects on the body:
Mandrax users
can develop physical and psychological dependence
on the drug, constantly craving
its effects, but needing more and more to
get the desired high.
Effects on the brain:
Mandrax use
alters the brain chemicals, suppressing
brain function so that the user becomes
like a zombie.
HALLUCINOGENS
These psychedelic drugs distort reality, plunging the user into a dream world where everything
is distorted and colours become audible and sounds visible. Taken in large quantities
they scramble your brain, resulting in delusions and hallucinations. They also rev up the
brain, causing mood swings that can vary from euphoria to the deepest depression or violence.
Sometimes the loss of self and depression can be so severe that suicide is possible.
8. Cannabis
Street names: dagga, weed, marijuana, dope, grass, pot, ganja, hash, hashish
In South Africa cannabis is grown in rural areas
and sold as a means to put food on the table.
Cannabis contains more than 426 known chemicals
including the mind-altering substances
known as THCs (tetrahydrocannabinols).
The heaven:
You feel euphoric and relaxed.
The hell
Panic attacks, hallucinations, flashbacks
and memory loss.
Effects on the body:
It causes frequent sinusitis
and bronchitis and may cause infertility in men
and women. Lung cancer is a real risk.
It may harm an unborn baby, leading to
miscarriage, stillbirth or early death. Fetal
marijuana syndrome – characterised by lower
birth weight and developmental abnormalities
– is five times more common than fetal alcohol
syndrome.
Effects on the brain:
THC changes the brain
chemistry that governs feelings, memory, the
senses and co-ordinated movement.
9. LSD
(LYSERGIC ACID DIETHYLAMIDE)
Street names: acid, blotter acid, microdot, white lightning
LSD is an odourless and colourless drug
available in two forms: paper stamps
impregnated with LSD or micro-tablets
(“microdots’’) containing LSD in very low
concentrations per tablet.
The heaven:
It seems as though you have
your senses crossed, giving you the feeling of
hearing colours and seeing sounds. Taken in
large enough doses, LSD produces delusions
and visual hallucinations.
The hell:
Mental disorders such as
schizophrenia and severe depression.
Effects on the body:
Increased heart
rate, increased blood pressure, numbness
and weakness.
Effects on the brain:
LSD affects
a large number of chemicals in the
brain, including the neurotransmitters
dopamine and serotonin. The drug may
also increase the levels of a substance called
glutamate in very specific parts of the brain,
overstimulating the brain cells and causing
an“electric storm’’ . Each electric stormcauses hallucinations,
but can lead to permanent changes.
SPYING ON YOUR BRAIN
New technology has allowed doctors to pinpoint the areas of the brain most
affected by drug abuse. One method is the brain Spect (single photon emission
computed tomography) which uses gamma rays to construct two- or
three-dimensional images of active brain regions.
With a brain Spect doctors can look at the damage done by impaired blood flow caused by various drugs, explains Dr Pieter Botha of the department of radiology at Tygerberg Hospital in Cape Town. Drugs such as alcohol, cocaine or marijuana impair the effectiveness of blood vessels in the brain, constricting blood flow to certain areas. On scans these affected areas show up as“holes” in the brain. The pictures above show the brain Spects of three different crack abusers. The colours on the scan indicate levels of brain activity. Red is best, with yellow, green and blue highlighting diminishing areas of activity.
FACT:
Nowadays more and
more drugs are manufactured
so they can be smoked
– this way the effect can be
experienced much faster. When
one smokes tik (methamphetamine),
for example, it reaches the
brain within 30 seconds and
gives you a high but when
swallowed it takes 10 to
15 minutes to get to
the brain.
THERE ARE FOUR STEPS TO DRUG DEPENDENCY
- The experimental stage.
- The recreational phase. You don’t actively try to acquire the drug, but partake when your friends offer it to you.
- The regular-use stage. You obtain the drug yourself and make sure you always have a stash. You use drugs once or twice a week.
- The dependency phase or addiction. At this stage drugs will be the most important thing in your life and any attempt to separate you from the drug will be met with fierce resistance. Drug addiction is a deadly disease if not treated. No wonder it’s described as a “journey to nowhere”.
This article was compiled with the help of one of South Africa’s leading drug experts, superintendent Casper Venter, a pharmacist in the chemical unit of the forensic science laboratory of the South African Police Service (SAPS); senior superintendent Deven Naicker, national head of narcotics at the SAPS; and the Medical Research Council.
YOU Pulse Summer 2007/8
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