10 November 2009


5-MeO-DMT is a psychoactive tryptamine which was first identified in the mid 20th Century as a chemical in a South American plant entheogen.

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5-MeO-DMT is sometimes confused with its more well-known cousin N,N-DMT (usually just called "DMT") which can lead to disasterous results because of the large difference in appropriate dosages (5-MeO-DMT's dosage is perhaps 1/10 to 1/2 that of N,N-DMT, depending on individual reaction).

The standard dosage range for smoked 5-MeO-DMT is between 2-15 mg; for insufflation the dose range is 5-20 mg. These are very small amounts of material and should be measured extremely carefully. Many people achieve full world-shattering effects at as low as 3-5 mg (8-12 insufflated) and it is not uncommon for individuals who smoke 20-30 mg to have psychological and mental difficulties lasting several weeks.

5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a naturally occurring chemical in the tryptamine class. It is related structurally to N,N-DMT, Bufotenine, Psilocybin, and Psilocin.

In the early 1950s, 5-MeO-DMT was identified as one of the main psychoactive ingredients in "cohoba" snuffs used in the northern Amazon basin. Its use in the form of snuffs and brews has been documented as early as the 8th Century A.D. from a burial site in Northern Chile which found snuffing paraphernalia and traces of N,N-DMT, 5-MeO-DMT and Bufotenine. Other archeological sites have also uncovered seeds of 5-MeO-DMT containing Anadenanthera species from around the same time period. Its use as a recreational psychoactive has increased through the 80's and 90's.

The Substance: 5-MeO-DMT; 5-MeO.
The Experience: Tripping; The Void.

The smoked 5-MeO-DMT experience is short, but generally incredibly intense. Onset is fast and furious, sometimes compared to being launched from a cannon. It is a fully engaging and enveloping experience of visions (actual visual effects less common) which varies greatly from one individual to the next. Users report profound changes in ontological perspective, experiencing the void, the shattering of the universe, frightening and overwhelming forces, complete shifts in perception and identity followed by an abrupt return to baseline.

When smoked, 5-MeO-DMT generally reaches full effects within 10-60 seconds of inhalation. Insufflated, effects come in generally within 5 minutes.

The primary effects of 5-MeO-DMT last approximately 5-20 minutes when smoked, 30-45 minutes when insufflated. For many people there is an additional period of time (one to two hrs) before fully returning to baseline. Some people find the 5-MeO-DMT experience difficult to integrate and experience unsettling thoughts and feelings for days after use.

One of the primary physical problems encountered with smoked 5-MeO-DMT is the harsh nature of the smoke which can cause throat and lung irritation. Integration of the experience can also cause difficulties for some individuals, especially at higher doses. Difficult integration periods can lead to anxiety, difficulty focusing on daily tasks, preoccupation with the experience, difficulty sleeping, etc. Generally these effects dissipate on their own over the course of a few days but there are reports of persisting problems.

The effects of smoked 5-MeO-DMT are dramatically increased if used by individuals currently taking MAOIs. MAOIs are most commonly found in the prescription anti-depressants phenelzine, tranylcypromine, isocarboxazid, l-deprenyl, and moclobemide. Check with your doctor if you are not sure whether your prescription medication is an MAOI.
Do not stand up. Do not operate heavy machinery. Do not drive.
Individuals currently in the midst of emotional or psychological upheaval in their everyday lives should be careful about choosing to use psychedelics such as 5-MeO-DMT as they can trigger even more difficulty.
Individuals with a family history of schizophrenia or early onset mental illness should be extremely careful because psychedelics have been known to trigger latent psychological and mental problems.

Addiction potential
5-MeO-DMT is neither physically addicting nor likely to cause psychological dependance. As with most substances, some people will use it more frequently than they are comfortable with. There is a short period of tolerance after 5-MeO-DMT use. Using 5-MeO-DMT a second time within a few hours is likely to lead to a significantly diminished experience the second time. Last modified April 2009.

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