Sydney - A contraceptive pill for men has moved one step closer after
Australian researchers successfully made male mice infertile.
The result was that even though the mice had sex normally and were otherwise
healthy, they were infertile, researcher Sabatino Ventura from Melbourne's
Monash University said.
Monash scientists genetically modified mice to block two proteins found on
the smooth muscle cells which are essential for sperm to travel through the
animal's reproductive organs.
"We've shown that simultaneously disrupting the two proteins that
control the transport of sperm during ejaculation causes complete male
infertility," Ventura said.
"But without affecting the long-term viability of sperm or the sexual
or general health of males. The sperm is effectively there, but the muscle is
just not receiving the chemical message to move it."
Ventura, who collaborated with researchers from the University of Melbourne
and Britain's University of Leicester on the study, now wants to replicate the
genetic process chemically and believes a male contraceptive pill could be
possible in about 10 years.
"The next step is to look at developing an oral male contraceptive
drug, which is effective, safe and readily reversible," he said.
Previous attempts to develop a male contraceptive pill have focused on
hormones or producing dysfunctional sperm - methods which can interfere with
male sexual activity and cause long-term and potentially irreversible effects
Ventura said because his approach was non-hormonal and did not impact on the
development of sperm, a drug which switched off the two proteins should not
have any long-term side effects and could be reversed once the man stopped
(Picture of father from Shutterstock)