08 December 2008

Science searches for CoQ10 benefits

As the science behind the understanding of coenzyme Q10 (CoQ10) expands, so does the list of potential health conditions and diseases that could benefit from supplements.

As the science behind the understanding of coenzyme Q10 (CoQ10) expands, so does the list of potential health conditions and diseases that could benefit from supplements.

CoQ10 has properties similar to vitamins, but since it is naturally synthesised in the body it is not classed as such. With chemical structure 2,3-dimethoxy-5-methyl-6-decaprenyl-1,4-benzoquinone, it is also known as ubiquinone because of its ‘ubiquitous’ distribution throughout the human body.

The coenzyme is concentrated in the mitochondria - the 'power plants' of the cell - and plays a vital role in the production of chemical energy by participating in the production of adenosince triphosphate (ATP), the body's so-called 'energy currency'.

A role beyond the mitochondria is also acknowledged, with CoQ10 acting as a potent antioxidant. The coenzyme plays an important role in preserving levels of vitamin E and vitamin C.

The formulation of the CoQ10 is reported to play a key role in its bioavailability. Since the coenzyme is lipophilic (fat-loving), its absorption is enhanced in the presence of lipids. However, when taken as a supplement apart from meals, the absorption of some formulations is lower.

Responses with CoQ10
Trials with CoQ10 supplements in powder and oil-suspension forms are reported to result in small or negligible responses in plasma CoQ10 concentrations.

According to a review of CoQ10 by Hemmi Bhagavan and Raj Chopra from Tishcon Corporation in New York (Free Radical Research, Vol. 40, pp. 445-453), solubilised formulations elicit a large response.

The majority of research looking at the benefits for health conditions has focused on the cardiovascular diseases. Heart tissue contains the highest concentration of CoQ10 in the human body (about 132 nanomoles per gram), along with the kidney (77 nanomoles per gram) and the liver (64 nanomoles per gram).

There is an ever-growing body of scientific data that shows substantial health benefits of CoQ10 supplementation for people suffering from angina, heart attack and hypertension. Clinical trials have also reported benefits for cardiomyopathy and congestive heart failure.

CoQ10 concentration in the human brain is reported to be only 15,5 nanomoles per gram, a relatively low concentration that is linked to the high rate of oxidative stress in this organ. For this reason, researchers are increasingly looking at the possible protective role of CoQ10 in the development of neurodegenerative diseases such as Parkinson’s and Alzheimer’s.

Tests linked to brain impairment
Indeed, a recent study in the journal Behavioural Brain Research (doi: 10.1016/j.bbr.2006.03.009) investigated the effects of supplementation of the diets of rats suffering from brain impairment by oxidative stress, presented as a model for Alzheimer’s.

The researchers reported a significant improvement in the loss of cognitive function, leading them to conclude that CoQ10 could play a role in the prevention of this disease.

And this highlights an important consideration with animal studies concerning CoQ10. While rats are extensively used for preliminary tests, it should be mentioned that guinea pigs might be more reliable models. The major form of coenzyme Q in rats is CoQ9, and not CoQ10 like in humans, and guinea pigs.

Other conditions explored
And the benefits of CoQ10 are being explored in relation to other conditions and diseases. Studies are emerging linking supplements of coenzyme to benefits for diabetes, cancer (breast, lung and prostate), male infertility, and kidney failure.

Clinical trials looking at the effects of coenzyme Q10 are on-going around the world, with research reported in countries such as the USA, Norway and Ecuador.

Source: Decision News Media

- June 2006

Read more:
On the pill? Consider supplements
Coenzyme Q10 - is it important for health?


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