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Question
Posted by: Renee | 2004/10/28

Will methotrexate reduce fertiltiy (in males)?

My husband has been using Methotrexate for about 2 years, he has stopped taking it about 4 weeks ago, will this have an impact on fertiltiy?

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Our expert says:
Expert ImageGynaeDoc

Opinions in the literature differ on the effects of methotrexate on male fertility. Several case reports and studies report no effect; others report reversible sterility. One limitation to several of these studies is the concurrent administration of other chemotherapeutic agents. Small studies reporting on methotrexate use with no other agents suggest no increased infertility.

Best wishes

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