Our expert says:
In our practice we come across Von Wilebrand disease very regularly and if not appropriately dealt with will continue to cause implantation failures. In most cases were the appropriate clotting factors have been replaced at the appropriate stage of the treatment we have had fairly good outcomes. I therefore would encourage you to pursue the ICSI option bearing in mind the latest development and to take the appropriate measures to correct the clotting disorder. It is quiet possible that the oral contraceptive, which usually encourages clot formation, may have further disrupted the delicate clotting factor profile and hence resulted in the aggravated bleeding. However it is also likely that the hormonal balance may have been altered by the contraceptive use resulting in irregular break down of the endometrium (lining of the womb) which manifest as a mid-cycle bleed or a break through bleed which is unfortunately exacerbated by the underlying clotting disorder.
Answered by: Dr M. I. Cassim
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