Our expert says:
All antidepressants, to the extent that they are useful, work towards exerting steady chemical changes, not effects you'd notice related to individual pills. After the initial period the aim, including that of XR and similar preparations, is to produce steady blood levels, which would NOT dip significantly through the day.
The aim of the XR is to produce steady levels throughout the day without needing to take multiple doses ; the main reason for choosing what time of day to take them is in regard to side-effects, which may be more evident sooner after taking the pill than later.
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