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Question
Posted by: Shirley | 2008/06/11

Urgent Advice Pls DR.

Doc,

Been TTCing for the past three years and period very irregular. Had been told of low progesterone and perhaps related to poor egg quality. To regulate period and also as a supplement, duphaston was prescribed to take 16-25th day of cycle. Can duphaston affect or interfere with my ability to conceive naturally or enhance it altogether. Your opinion would be much appreciated and from then on will decide on the course of action. Thank you...

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Our expert says:
Expert ImageFertility expert

Dear Shirley
In principle, the use of duphaston is not a bad idea. However the use of day 16 – 25 is somewhat inappropriate in that ideally it should be linked to the actual ovulation process itself. Duphaston should be commenced 4 – 5 days post - ovulation and maintained until a pregnancy can be confirmed and occasionally beyond that point as well. My advice is to use an ovulation induction agent in the initial stages of the menstrual cycle. This can be accomplished by the simple use of oral agents such as Clomiphene citrate (clomid/fertomid) from day 4 or 5 of the cycle. This should be coupled with ovulation monitoring using the urine LH testing kits and timed intercourse accordingly. The first one can then be introduced 4 or 5 days after ovulation has been confirmed. Should this process fail, then a tightly controlled ovulation induction cycle using ultrasound scanning as a guide should be considered.

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