Our expert says:
Dear Sally B
Inability to lose weight can be due to a variety of factors - some physical ones such as insulin resistance and thyroid deficiency (which in your wife's case can be ruled out) and some psychological ones of which depression is the main factor. If this is a possible cause then I would recommend that your wife should consult a psychiatrist for medication and a clinical psychologist for psychotherapy. It may also help her to use a an energy-reduced, low-fat, high-fibre diet (click on 'Diet' at the top of this page, 'Weight loss', ‘Balanced diet’ and then on 'Slimming Diet' for a copy of such a diet) in conjunction with her exercise. You don't mention what type of exercise your wife does, but so-called aerobic or cardio exercise (brisk walking, swimming, cycling, skipping, rowing, treadmill jogging, etc) is more effective for weightloss than static exercises with weights.
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