Our expert says:
The synephrine has the same effect as epinephrine. These compounds can cause dependence, addiction, tremors, insomnia, palpitations, irritability, psychotic reactions, etc. Products that contain epinephrine and synephrine have been banned in many countries because of their negative side-effects, which include addiction and dependence. The caffeine is also potentially addictive and may cause irritability, insomnia, and other central nervous system symptoms. Willow bark extract is similar to aspirin which if used in large quantities can cause bleeding ulcers.
Basically it is safer to avoid products that contain compounds that can cause negative side-effects and addiction.
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