Our expert says:
Unfortunately it is very difficult for me to even guess at what is wrong with your bunny on the information supplied. The weight loss would definitely worry me - have her teeth been checked? Straining to urinate and defecate could indicate an intestinal problem or possibly bladder stones (an x-ray could help here) or a pelvic problem, for starters. Have her feces been tested for parasites? I suggest you either talk to your vet again and try to find out exactly what they have ruled out and what the next step would be, or try to find a dedicated rabbit vet if your current vet is not fully au fait with the species. The houserabbit society has a good website (google the name) for further information.
Dr Willemien van Wyk
Bird and exotic animal veterinarian
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