Our expert says:
Reductil should not be used where there is a history of Depression.
5HTP is not a recognized treatment for significant depression, and NOT preferable to proper antidepressants.
You need a fresh assessment, in person, by a good local psychiatrist. If the sleep disturbance is related to the Depression, then proper treatment of the Depression should relieve the sleep concerns, too.
Now, as for your other, numbered, questions, those would take me hours, and pages and pages, to answer properly. I'm sure that elsewhere in H24 you will find, if you search the site, more material on serotonin, and a Google search will bring you loads of such material.
Lord knows how any particular GP chooses and AD --- in too many cases it may depend on what a pretty young drug rep was encouraging him to use. Seriously, it is hard to predict reliably which AD will best suiot which person, other than by trying some.
As for selective blocking, the issue is that where certain chemicals normally functioning in brain activity are effectively low, blocking their re-uptake ( normally they are released, and then after acting at a nerve ending, taken back into the nerve for later use ) leaves the smaller amount that is available around and active for longer, partly relieving the releative lack of that particular chemical. Selective means the effect is predominantly on that one specific chemical, rather than on several at once.
There is nothing even remotely "natural" about taking 5HTP --- I wish the law totally banned the use of the weasel word "Natural" in the promotion of any health-related product --- it is almost always a lie. 5HTP does not naturally occur in tablets of capsules, and is never naturally consumed as such, only as part of a normal diet and as present within or dervied from, some foodstuffs. ANd there is nothing beneficial as such abotu something which is "natural" --- arsenic and struchnine are also entirely natursl substances, but they are very very bad for us.
If 5HTP taken by mouth was as effective as ADs, doctors would prescribe it instead of ADs. But it isn't so they dont.
There isn;'t a single shred of good scientific evidence that products like 5HTP are any "healthier" than proper ADs --- dont too easily believe the self-serving advertising for "natural" products.
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