Posted by: Anonymous | 2009/06/06

Luteinised unruptured follicle syndrome (LUF)

What is LUF? Can it be treated or is IVF the only option?

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Our expert says:
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Dear Anonymous

The LUF syndrome is a situation were the ovarian follicle develops initially in a normal manner up to the point of ovulation. However at this juncture the follicle fails to release the egg and undergoes luteinization (changes in the cell type within the follicle occurs and progesterone production proceed in the normal manner as if ovulation has occurs). However the failure to release the egg or the implosion of the follicle prevents fertilization from occurring. In order to overcome this problem IVF is certainly the first line of treatment. However in selected cases aggressive ovulation induction may result in successful ovulation from a few follicles since it is unlikely that all the follicles will undergo similar luteinization.

Answered by: Dr M.I. Cassim

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