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Question
Posted by: jen d | 2007/03/11

epinutin

hi there, havin a bit of trouble gettin info on epinutin.please could you tell me the indications for takin epinutin for a patient that has suffered a stroke,possible side effects of the drug,contra-indications and how the drug works in the body?

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Our expert says:
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Epanutin is normally indicated for use in patients with seizure. Should this not be the case in the patient you are referring to, it may be that your doctor is using one f its "off-lable" uses. Speak to him about this.

Epanutin is indicated for the control of grand mal and psychomotor seizures.
Phenytoin is an anticonvulsant. The primary site of action appears to be the motor cortex where the spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, phenytoin tends to stabilise the threshold against hyper-excitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of post-tetanic potentiation at synapses. Loss of post-tetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas. Phenytoin reduces the maximal activity of brain stem centres responsible for the tonic phase of grand mal seizures.
Side-effects of phenytoin include nausea, vomiting, constipation, ataxia, slurred speech, blurred vision, diplopia, nystagmus, mental confusion and hallucinations together with headache, dizziness, transient nervousness, motor twitching, toxic hepatitis, liver damage periarteritis nodosa and insomnia. Some of these effects may disappear with continued treatment at reduced dosage.

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